P3755

6-Propyl-2-Thiouracil

enzyme inhibitor

• Synonym(e): 2,3-Dihydro-6-propyl-2-thioxo-4(1H)-pyrimidinon, 4-Hydroxy-2-mercapto-6-propyl-pyrimidin
• Empirische Formel (Hill-System): C₇H₁₀N₂OS
• CAS-Nummer: 51-52-5
• Molekulargewicht: 170.23
• Beilstein: 130039
• EG-Nummer: 200-103-2
• MDL-Nummer: MFCD00006041
• UNSPSC-Code: 41106305
• PubChem Substanz-ID: 24898446
• NACRES: NA.51

Eigenschaften

• Beschreibung: enzyme inhibitor
• Qualitätsniveau: 200
• Assay: ≥99% (HPLC)
• Form: powder
• mp (Schmelzpunkt): 218-220 °C (lit.)
• Löslichkeit: 10% NH₃: 100 mg/mL, clear to slightly hazy, colorless to faintly yellow
• SMILES String: CCCC1=CC(=O)NC(=S)N1
• InChI: 1S/C7H10N2OS/c1-2-3-5-4-6(10)9-7(11)8-5/h4H,2-3H2,1H3,(H2,8,9,10,11)
• InChIKey: KNAHARQHSZJURB-UHFFFAOYSA-N
• Angaben zum Gen: human ... DIO1(1733) , TPO(7173)

Beschreibung

Allgemeine Beschreibung

6-Propyl-2-thiouracil or 6-n-Propylthiouracil (PROP) is a compound with a bitter taste.

Anwendung

6-Propyl-2-thiouracil (PROP) has been used to impregnate on disk for PROP taster status studies for sensory characterization in a defined human sample group. It has been used as a screening agent for testing the intensity of taste by labeled magnitude scale (LMS).

6-Propyl-2-thiouracil is a thyreostatic (thyroid hormone) agent that may be used as a reference material in thyreostatic drug separation and detection technologies such as capillary electrophoresis, high performance liquid chromatography (HPLC), or gas chromatography.

Biochem./physiol. Wirkung

6-Propyl-2-thiouracil (6-PTU), a potential inhibitor of D1 iodothyronine deiodinase, is involved in the deiodination of iodothyronines. It is an uncompetitive inhibitor of iodothyronine substrates.

Sicherheitshinweise

• Piktogramme: GHS08,GHS07
• Signalwort: Warning
• H-Sätze: H302,H351
• P-Sätze: P201 - P301 + P312 + P330 - P308 + P313
• Gefahreneinstufungen: Acute Tox. 4 Oral - Carc. 2
• Lagerklassenschlüssel: 11 - Combustible Solids
• WGK: WGK 3
• Flammpunkt (°F): Not applicable
• Flammpunkt (°C): Not applicable
• Persönliche Schutzausrüstung: Eyeshields, Gloves, type P3 (EN 143) respirator cartridges