P0608

Anti-Potassium Channel SK3 (KCa3, Kcnn3, SKCa3) antibody produced in rabbit

affinity isolated antibody, lyophilized powder

• Synonym(e): Anti-KCa2.3, Anti-SK3, Anti-SKCA3, Anti-ZLS3, Anti-hSK3
• MDL-Nummer: MFCD02097224
• UNSPSC-Code: 12352203
• NACRES: NA.41

Eigenschaften

• Biologische Quelle: rabbit
• Qualitätsniveau: 100
• Konjugat: unconjugated
• Antikörperform: affinity isolated antibody
• Antikörper-Produkttyp: primary antibodies
• Klon: polyclonal
• Form: lyophilized powder
• Speziesreaktivität: rat, human
• Methode(n): western blot (chemiluminescent): 1:200 using rat brain membranes
• UniProt-Hinterlegungsnummer: Q9UGI6
• Lagertemp.: −20°C
• Posttranslationale Modifikation Target: unmodified
• Angaben zum Gen: human ... KCNN3(3782) ; rat ... Kcnn3(54263)

Beschreibung

Allgemeine Beschreibung

The calcium-activated potassium ion channel (KCNN3) is a voltage-independent small-conductance calcium-activated potassium channel. It is abundantly expressed in the brain and central nervous system. Its predominant expression is seen in the hypothalamus. KCNN3 gene is located on human chromosome 1q21.3.

Immunogen

synthetic peptide corresponding to amino acids 2-21 of human potassium channel SK3. The epitope is highly homologous in rat.

Anwendung

Anti-Potassium Channel SK3 (KCa3, KCNN3, SKCa3) antibody produced in rabbit has been used in western blot analysis (1:250) and immunohistochemical staining (1:50).

Biochem./physiol. Wirkung

Anti-Potassium channel SK3 recognizes the SK3 protein in humans and rats by immunoblotting. Potassium channels contribute to maintaining cell volume, membrane potential, neuronal excitability, and the secretion of transmitters, salt, and hormones. It is extremely sensitive to changes in intracellular calcium levels, which are common during action potentials. KCNN3 helps to determine neuronal firing rates via the after-hyperpolarization. It is a migraine candidate susceptibility gene. Aberrations in the KCNN3 gene may trigger cortical spreading depression (CSD) and trigeminal sensitivity.

Physikalische Form

Lyophilized at ~0.6 mg/ml from phosphate buffered saline, pH 7.4, containing 1% bovine serum albumin, and 0.05% sodium azide.

Haftungsausschluss

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

Sicherheitshinweise

• Lagerklassenschlüssel: 11 - Combustible Solids
• WGK: WGK 2