O4139

Orlistat

≥98% (HPLC), solid, lipase inhibitor

• Synonym(e): (−)-Tetrahydrolipstatin, N-Formyl-L-leucin-(1S)-1-{[(2S,3S)-3-hexyl-4-oxo-2-oxetanyl]-methyl}-dodecylester, Ro-18-0647
• Empirische Formel (Hill-System): C₂₉H₅₃NO₅
• CAS-Nummer: 96829-58-2
• Molekulargewicht: 495.73
• MDL-Nummer: MFCD05662360
• UNSPSC-Code: 41106300
• PubChem Substanz-ID: 24724564
• NACRES: NA.77

Eigenschaften

• product name: Orlistat, ≥98%, solid
• Biologische Quelle: synthetic (organic)
• Assay: ≥98%
• Form: solid
• Farbe: white
• mp (Schmelzpunkt): <50 °C
• Löslichkeit: DMSO: 19 mg/mL
• Ersteller: Roche
• Lagertemp.: 2-8°C
• SMILES String: CCCCCCCCCCC[C@@H](C[C@@H]1OC(=O)[C@H]1CCCCCC)OC(=O)[C@H](CC(C)C)NC=O
• InChI: 1S/C29H53NO5/c1-5-7-9-11-12-13-14-15-16-18-24(34-29(33)26(30-22-31)20-23(3)4)21-27-25(28(32)35-27)19-17-10-8-6-2/h22-27H,5-21H2,1-4H3,(H,30,31)/t24-,25-,26-,27-/m0/s1
• InChIKey: AHLBNYSZXLDEJQ-FWEHEUNISA-N
• Angaben zum Gen: human ... LIPF(8513) , PNLIP(5406)

Beschreibung

Allgemeine Beschreibung

Orlistat acts as a gastric lipase inhibitor that reduces fat absorption.

Anwendung

Orlistat has been used as an inhibitor:

• of fatty acid synthase in long-term estrogen-deprived (LTED) variant cell lines
• of lipase in screening lipase inhibition by raspberry extract
• in in vitro pancreatic lipase activity assay

Biochem./physiol. Wirkung

Orlistat impairs intestinal fat absorption and is effective in weight management. It is regarded as a safe drug for treating obesity. It delays the progression of type 2 diabetes mellitus especially in obese and improves glycemic parameters. Long term usage of orlistat results in improved weight reduction and it may not contribute in colorectal carcinogenesis.

Orlistat, used in obesity research, is a pancreatic lipase inhibitor that acts locally in the gastrointestinal tract to inhibit lipase.

Leistungsmerkmale und Vorteile

This compound was developed by Roche. To browse the list of other pharma-developed compounds and Approved Drugs/Drug Candidates, click here.

Sonstige Hinweise

Solution is not completely clear, small particles may remain floating.

Sicherheitshinweise

• Lagerklassenschlüssel: 11 - Combustible Solids
• WGK: WGK 3
• Flammpunkt (°F): Not applicable
• Flammpunkt (°C): Not applicable
• Persönliche Schutzausrüstung: Eyeshields, Gloves, type N95 (US)