N7537

NSC 663284

≥98% (HPLC), solid

• Synonym(e): 6-Chloro-7-(2-morpholin-4-yl-ethylamino)quinoline-5,8-dione
• Empirische Formel (Hill-System): C₁₅H₁₆ClN₃O₃
• CAS-Nummer: 383907-43-5
• Molekulargewicht: 321.76
• MDL-Nummer: MFCD08276924
• UNSPSC-Code: 12352200
• PubChem Substanz-ID: 24724556
• NACRES: NA.77

Eigenschaften

• Qualitätsniveau: 100
• Assay: ≥98% (HPLC)
• Form: solid
• Lagerbedingungen: protect from light
• Farbe: red
• Löslichkeit: DMSO: ≥10 mg/mL; H₂O: insoluble
• Lagertemp.: 2-8°C
• SMILES String: ClC1=C(NCCN2CCOCC2)C(=O)c3ncccc3C1=O
• InChI: 1S/C15H16ClN3O3/c16-11-13(18-4-5-19-6-8-22-9-7-19)15(21)12-10(14(11)20)2-1-3-17-12/h1-3,18H,4-9H2
• InChIKey: BMKPVDQDJQWBPD-UHFFFAOYSA-N
• Angaben zum Gen: human ... CDC25B(994) , DUSP3(1845) , PTPN1(5770)

Beschreibung

Anwendung

NSC 663284 has been used as a cell division cycle 25 (CDC25) inhibitor to study its effects on the level of kizuna (kiz) dephosphorylation. It has also been used as a control in horseradish peroxidase/phenol red based assay and resazurin-based redox assay.

Biochem./physiol. Wirkung

NSC 663284 is a quinolinediones, which is involved in the inhibition of cell cycle progression at both G1 and G2/M phase. It is also involved in inhibiting the dephosphorylation and activation of cyclin-dependent kinases (Cdks) in vitro and in vivo. NSC 663284 stops the proliferation of various tumor cell lines.

Potent, irreversible, cell permeable and mixed competitive CDC25 phosphatase family inhibitor

Sicherheitshinweise

• Lagerklassenschlüssel: 11 - Combustible Solids
• WGK: WGK 3
• Flammpunkt (°F): 470.1 °F
• Flammpunkt (°C): 243.4 °C
• Persönliche Schutzausrüstung: dust mask type N95 (US), Eyeshields, Gloves