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N0665

Sigma-Aldrich

NDSB 211

≥98% (TLC)

Synonym(e):

3-[Dimethyl-(2-hydroxyethyl)ammonio]-1-propanesulfonate, Dimethyl(2-hydroxyethyl)(3-sulfopropyl)ammonium hydroxide inner salt, Dimethyl-2-hydroxyethylammoniumpropane sulfonate

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About This Item

Empirische Formel (Hill-System):
C7H17NO4S
CAS-Nummer:
38880-58-9
Molekulargewicht:
211.28
EG-Nummer:
254-176-0
MDL-Nummer:
MFCD01320397
UNSPSC-Code:
12161900
PubChem Substanz-ID:
329818450
NACRES:
NA.25

Beschreibung

zwitterionic

Assay

≥98% (TLC)

Form

solid

Mol-Gew.

211.28 g/mol

Methode(n)

DNA extraction: suitable

Farbe

white

Löslichkeit

methanol: 5 mg/mL, clear, colorless

SMILES String

OCC[N+](C)(C)CCCS([O-])(=O)=O

InChI

1S/C7H17NO4S/c1-8(2,5-6-9)4-3-7-13(10,11)12/h9H,3-7H2,1-2H3

InChIKey

CNXPCGBLGHKAIL-UHFFFAOYSA-N

Allgemeine Beschreibung

Dimethyl-2-hydroxyethylammoniumpropane sulfonate, or NDSB 211, is a nondetergent-sulfobetain. It is zwitterionic over a wide pH range, easily removed by dialysis and shows no significant absorption in the near UV range.

Anwendung

NDSB 211 has been used in a study to assess halophilic protein stabilization by the mild solubilizing agents nondetergent sulfobetaines. It has also been used in a study to investigate an alternative strategy for crystallizing macromolecules.
Non-detergent sulfobetaine is a compound used for non-denaturing protien purification. Increases the extraction yield of membrane, nuclear and cytoskeletal associated proteins. Zwitterionic over a wide pH range, easily removed by dialysis and no significant absorption in the near UV range. Specific applications include microsomal protein extraction, nuclear protein recovery, precipitation reduction in IEF, and membrane-bound protease purification.

Sonstige Hinweise

This product is non-micelle forming.

Piktogramme

Corrosion
GHS05

Signalwort

Danger

H-Sätze

H314

Gefahreneinstufungen

Skin Corr. 1B

Lagerklassenschlüssel

8A - Combustible corrosive hazardous materials

WGK

WGK 3

Flammpunkt (°F)

Not applicable

Flammpunkt (°C)

Not applicable

Analysenzertifikate (COA)

Suchen Sie nach Analysenzertifikate (COA), indem Sie die Lot-/Chargennummer des Produkts eingeben. Lot- und Chargennummern sind auf dem Produktetikett hinter den Wörtern ‘Lot’ oder ‘Batch’ (Lot oder Charge) zu finden.

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Die Dokumentenbibliothek aufrufen

L Vuillard et al.
Analytical biochemistry, 230(2), 290-294 (1995-09-20)
In this work, experiments performed on pig heart and halophilic malate dehydrogenase as well as halophilic elongation factor Tu demonstrate a protein stabilization property from the recently described mild solubilizing agents nondetergent sulfobetaines. A practical application is given by the
Searching for silver bullets: An alternative strategy for crystallizing macromolecules
McPhersona, A., et al.
Journal of Structural Biology, 156, 3887-3406 (2006)
Ivanka M Karadzic et al.
Proteomics, 5(2), 354-359 (2005-01-04)
Proteins of haloarchaea are remarkably unstable in low-ionic-strength solvents and tend to aggregate under standard two-dimensional (2-D) gel electrophoresis conditions, causing strong horizontal streaking. We have developed a new approach to generate 2-D maps of halophilic proteins which included washing

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