M9170
Macrophage Colony-Stimulating Factor from mouse
≥98% (SDS-PAGE), recombinant, expressed in E. coli, lyophilized powder, suitable for cell culture
Synonym(e):
CSF-1
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Alle Fotos(2)
About This Item
CAS-Nummer:
EG-Nummer:
MDL-Nummer:
UNSPSC-Code:
12352202
eCl@ss:
32190102
NACRES:
NA.77
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product name
Macrophage Colony-Stimulating Factor from mouse, recombinant, expressed in E. coli, lyophilized powder, suitable for cell culture
Qualitätsniveau
UniProt-Hinterlegungsnummer
Angaben zum Gen
mouse ... Csf1(12977)
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Anwendung
Macrophage Colony-Stimulating Factor from mouse has been used:
- in the initiation of osteoclastogenesis in bone marrow monocyte cells
- to stimulate osteoclast differentiation in non-adherent hematopoietic cell
- for the generation of blood-derived stem cells
Biochem./physiol. Wirkung
Macrophage Colony Stimulating Factor (M-CSF), also known as CSF-1, can be produced by a number of cells, including fibroblasts, monocytes, activated macrophages, secretory epithelial cells of the endometrium, endothelial cells activated by LPS or cytokines, and bone marrow stromal cells. In addition to its namesake activity, M-CSF can stimulate the proliferation of isolated macrophages, augment the production and release of cytokines and other inflammatory modulators from macrophages, enhance macrophage antibody-dependent cell-mediated cytotoxicity, prime and enhance macrophages in their ability to kill tumor cells and other microorganisms, stimulate pinocytosis, and support osteoclast differentiation. M-CSF binds and activates a 165 kDa glycoprotein of the receptor tyrosine kinase subclass III or the RTK subfamily. Due to alternative splicing of a single M-CSF gene and due to variations in glycosylation, the molecular weight of natural soluble M-CSF ranges from 44-86 kDa. Human and mouse M-CSF share approximately 80% sequence homology in the conserved N-terminal region of 150 amino acids. Although human M-CSF is active in murine systems, mouse M-CSF appears to be species-specific in its actions.
Physikalische Form
Lyophilized from a sterile filtered buffered aqueous solution.
Hinweis zur Analyse
The proliferative activity is tested by the dose-dependent stimulation of the murine monocytic cell line, M-NFS-60.
Signalwort
Warning
H-Sätze
P-Sätze
Gefahreneinstufungen
Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3
Lagerklassenschlüssel
11 - Combustible Solids
WGK
WGK 2
Flammpunkt (°F)
Not applicable
Flammpunkt (°C)
Not applicable
Persönliche Schutzausrüstung
dust mask type N95 (US), Eyeshields, Gloves
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Elisabeth A Diget et al.
Mediators of inflammation, 2013, 208412-208412 (2013-02-23)
Macrophages play an important role in human immunodeficiency virus (HIV) pathogenesis and contribute to establishment of a viral reservoir responsible for continuous virus production and virus transmission to T cells. In this study, we investigated the differences between various monocyte-derived
B F Boyce
Journal of dental research, 92(10), 860-867 (2013-08-03)
Osteoclasts are derived from mononuclear hematopoietic myeloid lineage cells, which are formed in the bone marrow and are attracted to the bloodstream by factors, including sphingsine-1 phosphate. These circulating precursors are attracted to bone surfaces undergoing resorption by chemokines and
Filamin A regulates monocyte migration through Rho small GTPases during osteoclastogenesis
Leung R, et al.
Journal of Bone and Mineral Research, 25(5), 1077-1091 (2010)
Strain differences in the attenuation of bone accrual in a young growing mouse model of insulin resistance
Rendina-Ruedy E, et al.
Journal of Bone and Mineral Metabolism, 34(4), 380-394 (2016)
Yan Li et al.
Journal of immunology (Baltimore, Md. : 1950), 191(6), 3192-3199 (2013-08-13)
Engraftment of human CD34⁺ hematopoietic stem/progenitor cells into immunodeficient mice leads to robust reconstitution of human T and B cells but not monocytes and macrophages. To identify the cause underlying the poor monocyte and macrophage reconstitution, we analyzed human myeloid
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