M6057

Anti-Matrix Metalloproteinase-12, Propeptide Region antibody produced in rabbit

~1 mg/mL, affinity isolated antibody, buffered aqueous glycerol solution

• Synonym(e): Anti-MMP-12
• MDL-Nummer: MFCD03455403
• UNSPSC-Code: 12352203
• NACRES: NA.41

Eigenschaften

• Biologische Quelle: rabbit
• Qualitätsniveau: 200
• Konjugat: unconjugated
• Antikörperform: affinity isolated antibody
• Antikörper-Produkttyp: primary antibodies
• Klon: polyclonal
• Form: buffered aqueous glycerol solution
• Mol-Gew.: antigen 54 kDa
• Speziesreaktivität: human
• Konzentration: ~1 mg/mL
• Methode(n): western blot: 1:3,000
• UniProt-Hinterlegungsnummer: P39900
• Versandbedingung: wet ice
• Lagertemp.: −20°C
• Posttranslationale Modifikation Target: unmodified
• Angaben zum Gen: human ... MMP12(4321)

Beschreibung

Allgemeine Beschreibung

Matrix metalloproteinase-12 (MMP-12) is also called as macrophage metalloelastase and is secreted by inflammatory macrophages. It is synthesized as a zymogen and then activated by cleaving the propeptide domain. The MMP-12 gene is localized on human chromosome 11.

Spezifität

The antibody recognizes only the latent form of MMP-12 and not the active forms. May be used to distinguish the zymogen and the activated enzyme.

Immunogen

synthetic peptide corresponding to the propeptide region of human matrix metalloproteinase-12 (macrophage elastase).

Biochem./physiol. Wirkung

Matrix metalloproteinase-12 (MMP-12) is involved in breaking down proteoglycans, collagen type IV and laminin. Its main substrate is elastin.

Physikalische Form

Solution in 0.01 M phosphate buffered saline, pH 7.4, containing 50% glycerol and 15 mM sodium azide.

Haftungsausschluss

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

Sicherheitshinweise

• Lagerklassenschlüssel: 10 - Combustible liquids