M0695

Anti-MOG (N-terminal) antibody produced in rabbit

affinity isolated antibody, buffered aqueous solution

• Synonym(e): Anti-Myelin-oligodendrocyte Glycoprotein
• MDL-Nummer: MFCD08705481
• UNSPSC-Code: 12352203
• NACRES: NA.41

Eigenschaften

• Biologische Quelle: rabbit
• Qualitätsniveau: 200
• Konjugat: unconjugated
• Antikörperform: affinity isolated antibody
• Antikörper-Produkttyp: primary antibodies
• Klon: polyclonal
• Form: buffered aqueous solution
• Speziesreaktivität: human
• Methode(n): western blot: 1-2 μg/mL using recombinant human MOG protein
• UniProt-Hinterlegungsnummer: Q16653
• Versandbedingung: dry ice
• Lagertemp.: −20°C
• Posttranslationale Modifikation Target: unmodified
• Angaben zum Gen: human ... MOG(4340)

Beschreibung

Allgemeine Beschreibung

Myelin/oligodendrocyte glycoprotein (MOG) is an integral membrane glycoprotein belonging to the large immunoglobulin superfamily. It is a 26-28kDa glycoprotein localized on chromosome 6p21.3. It consists of an extracellular immunoglobulin-like domain and two hydrophobic regions. It is expressed on the surface of myelinating oligodendrocytes and external lamellae of myelin sheaths in the central nervous system.

Immunogen

synthetic peptide corresponding to amino acids 84-100 located near the N-terminal region of human MOGα1 isoform, conjugated to KLH. This sequence is identical in human MOGα1-3 and MOGβ1-4 isoforms, deleted in MOGα4 isoform, and identical in rat, mouse, and bovine MOG.

Anwendung

Anti-MOG (N-terminal) antibody produced in rabbit is suitable for western blot at a concentration of 1-2μg/mL using recombinant human MOG protein.

Biochem./physiol. Wirkung

Myelin/oligodendrocyte glycoprotein (MOG) is a major component of the central nervous system. It is involved in several cellular processes including cellular adhesion, in the regulation of oligodendrocyte microtubule stability and facilitates the interactions between myelin and the immune system. It has been reported that MOG may be involved in the completion and/or maintenance of the myelin sheath, and in cell-cell communication. It has also been observed that mutation or polymorphisms in MOG gene could cause multiple sclerosis.

Physikalische Form

Solution in 0.01 M phosphate buffered saline, pH 7.4, containing 15 mM sodium azide.

Haftungsausschluss

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

Sicherheitshinweise

• Lagerklassenschlüssel: 10 - Combustible liquids
• WGK: WGK 3
• Flammpunkt (°F): Not applicable
• Flammpunkt (°C): Not applicable
• Persönliche Schutzausrüstung: Eyeshields, Gloves, multi-purpose combination respirator cartridge (US)