K3125

Kojisäure

• Synonym(e): 2-Hydroxymethyl-5-hydroxy-γ-pyron, 5-Hydroxy-2-hydroxymethyl-4-pyranon, Cojisäure
• Empirische Formel (Hill-System): C₆H₆O₄
• CAS-Nummer: 501-30-4
• Molekulargewicht: 142.11
• Beilstein: 120895
• EG-Nummer: 207-922-4
• MDL-Nummer: MFCD00006580
• UNSPSC-Code: 12352106
• PubChem Substanz-ID: 24896226
• NACRES: NA.77

Eigenschaften

• Assay: ≥98.5% (HPLC)
• Qualitätsniveau: 200
• Form: powder
• mp (Schmelzpunkt): 152-155 °C (lit.)
• SMILES String: OCC1=CC(=O)C(O)=CO1
• InChI: 1S/C6H6O4/c7-2-4-1-5(8)6(9)3-10-4/h1,3,7,9H,2H2
• InChIKey: BEJNERDRQOWKJM-UHFFFAOYSA-N

Beschreibung

Anwendung

Kojic acid has been used:

• as an inhibitor of tyrosinase in guinea pigs pigmented hyperopic (PH)
• as a reference inhibitor standard for screening tyrosinase inhibition
• as a positive control for inhibition of tyrosinase in B16F10 melanoma cells

Biochem./physiol. Wirkung

Kojic acid is derived from some fungal species such as, Aspergillus, Acetobacter and Penicillium.. It halts melanin synthesis by inhibiting tyrosinase enzyme. It is used in the preparation of skin whitening cosmetics. However, kojic acid usage is minimal in cosmetics, as it induces skin irritation by its unstability and cytotoxic nature during long storage. It is an antioxidant and elicits radioprotective effects on chelating with manganese and zinc.

Tyrosinase-Inhibitor.

Sicherheitshinweise

• Lagerklassenschlüssel: 11 - Combustible Solids
• WGK: WGK 1
• Flammpunkt (°F): Not applicable
• Flammpunkt (°C): Not applicable
• Persönliche Schutzausrüstung: Eyeshields, Gloves, type N95 (US)