K1639

K-252a

from Nonomuraea longicatena, ≥98% (HPLC)

• Synonym(e): K-252a
• Empirische Formel (Hill-System): C₂₇H₂₁N₃O₅
• CAS-Nummer: 99533-80-9
• Molekulargewicht: 467.47
• MDL-Nummer: MFCD00161522
• UNSPSC-Code: 12352200
• PubChem Substanz-ID: 24896210
• NACRES: NA.77

Eigenschaften

• Biologische Quelle: Nonomuraea longicatena
• Qualitätsniveau: 200
• Assay: ≥98% (HPLC)
• Form: solid
• Löslichkeit: DMF: 1 mg/mL; DMSO: 1 mg/mL
• Wirkungsspektrum von Antibiotika: viruses
• Wirkungsweise: enzyme | inhibits
• Versandbedingung: dry ice
• Lagertemp.: −20°C
• SMILES String: [H][C@]12C[C@](O)(C(=O)OC)[C@](C)(O1)n3c4ccccc4c5c6CNC(=O)c6c7c8ccccc8n2c7c35
• InChI: 1S/C27H21N3O5/c1-26-27(33,25(32)34-2)11-18(35-26)29-16-9-5-3-7-13(16)20-21-15(12-28-24(21)31)19-14-8-4-6-10-17(14)30(26)23(19)22(20)29/h3-10,18,33H,11-12H2,1-2H3,(H,28,31)/t18-,26+,27+/m1/s1
• InChIKey: KOZFSFOOLUUIGY-SOLYNIJKSA-N
• Angaben zum Gen: human ... NTRK1(4914) ; rat ... Prkca(24680)

Beschreibung

Anwendung

K-252a has been used:

• as a tropomyosin receptor kinase (Trk) inhibitor to study the role of TrkA signaling in rats
• as a Trk inhibitor for inducing in vitro injury in retinal Müller glial cells to study the effects of cord blood serum (CBS)
• as a general protein kinase inhibitor to study its effect on in vitro human somatic testicular cell reassembly

Biochem./physiol. Wirkung

K-252a is a selective inhibitor of tyrosine protein kinase. It targets a wide range of protein kinases with IC₅₀ values between 3 and 25nM and the neurotrophin receptor-tropomyosin receptor kinase.

Sicherheitshinweise

• Lagerklassenschlüssel: 11 - Combustible Solids
• WGK: WGK 3
• Flammpunkt (°F): Not applicable
• Flammpunkt (°C): Not applicable
• Persönliche Schutzausrüstung: Eyeshields, Gloves, type N95 (US)