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I6160
ITK (352-end), active, GST tagged human
PRECISIO® Kinase, recombinant, expressed in baculovirus infected Sf9 cells, ≥70% (SDS-PAGE), buffered aqueous glycerol solution
Synonym(e):
EMT, LYK, MG C126257, MGC126258, PSCTK2
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About This Item
UNSPSC-Code:
12352200
NACRES:
NA.32
Empfohlene Produkte
Rekombinant
expressed in baculovirus infected Sf9 cells
Qualitätsniveau
Produktlinie
PRECISIO® Kinase
Assay
≥70% (SDS-PAGE)
Form
buffered aqueous glycerol solution
Spezifische Aktivität
49-67 nmol/min·mg
Mol-Gew.
~53 kDa
UniProt-Hinterlegungsnummer
Versandbedingung
dry ice
Lagertemp.
−70°C
Angaben zum Gen
human ... ITK(3702)
Allgemeine Beschreibung
ITK (IL2-inducible T-cell kinase) is a member of the Tec family of tyrosine kinases. ITK is expressed in T-cells.
Biochem./physiol. Wirkung
ITK (IL2-inducible T-cell kinase) is important for T-cell activation through the T-cell antigen receptor. Absence of ITK in T cells causes impairment in TCR (T cell receptor)-mediated actin polymerization, cell polarization and signaling events associated with cytoskeletal reorganization.
Physikalische Form
Supplied in 50 mM Tris-HCl, pH 7.5, with 150 mM NaCl, 0.2 5mM DTT, 0.1 mM EGTA, 0.1 mM EDTA, 0.1 mM PMSF, and 25% glycerol.
Rechtliche Hinweise
PRECISIO is a registered trademark of Merck KGaA, Darmstadt, Germany
Lagerklassenschlüssel
10 - Combustible liquids
WGK
WGK 1
Flammpunkt (°F)
Not applicable
Flammpunkt (°C)
Not applicable
Persönliche Schutzausrüstung
Eyeshields, Gloves, multi-purpose combination respirator cartridge (US)
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Lisa D Finkelstein et al.
Trends in cell biology, 14(8), 443-451 (2004-08-17)
Following stimulation, T cells undergo marked actin-dependent changes in shape that are required for productive cellular interactions and movement during immune responses. Reorganization of the actin cytoskeletal is also necessary for the formation of an immunological synapse - the convergence
Avery August et al.
The international journal of biochemistry & cell biology, 34(10), 1184-1189 (2002-07-20)
ITK and Rlk/Txk are the predominant Tec family of tyrosine kinases expressed in T cells, and are involved in T cell antigen receptor mediated activation of T cells. These kinases require prior activation of Lck, Zap-70 and PI3-kinase for efficient
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