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Merck

I5385

Sigma-Aldrich

Monoclonal Anti-Human IgG1 (Fab specific) [G1m(f)] antibody produced in mouse

clone SG-16, ascites fluid

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About This Item

MDL-Nummer:
UNSPSC-Code:
12352203
NACRES:
NA.46

Biologische Quelle

mouse

Qualitätsniveau

Konjugat

unconjugated

Antikörperform

ascites fluid

Antikörper-Produkttyp

secondary antibodies

Klon

SG-16, monoclonal

Enthält

15 mM sodium azide

Methode(n)

indirect ELISA: 1:5,000

Isotyp

IgG1

Versandbedingung

dry ice

Lagertemp.

−20°C

Posttranslationale Modifikation Target

unmodified

Allgemeine Beschreibung

Monoclonal Anti-Human IgG1 (mouse IgG1isotype) is derived from the hybridoma produced by the fusion of mouse myeloma cells and splenocytes from an immunized mouse. Human IgGs are glycoprotein antibodies that contain two equivalent light chains and a pair of identical heavy chains. IgGs have four distinct isoforms, ranging from IgG1 to IgG4.

Immunogen

Purified human IgG

Anwendung

Monoclonal anti-Human IgG1 may be used for the identification of human IgG1 subclass by means of various immunoassays. It can be used in direct hemagglutination (HA) and hemagglutination inhibition (HAI) assays, immunofluorometric assay (IFMA) and detection of cytoplasmic IgG. Monoclonal anti-human IgG1 has been used in enzyme linked immunosorbent assay (ELISA).

Biochem./physiol. Wirkung

Human IgGs regulate immunological responses to allergy and pathogenic infections. IgGs have also been implicated in complement fixation and autoimmune disorders This product clone recognizes the G1m(f) allotype and has been established as a useful human IgG1 specificity standard by the WHO/IUIS study.

Haftungsausschluss

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

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Lagerklassenschlüssel

10 - Combustible liquids

WGK

nwg

Flammpunkt (°F)

Not applicable

Flammpunkt (°C)

Not applicable


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Die Dokumentenbibliothek aufrufen

Allotype analysis to distinguish the origin of varicella-zoster virus immunoglobulin G after allogeneic stem cell transplantation
Yamazaki R, et al.
Biology of Blood and Marrow Transplantation : Journal of the American Society For Blood and Marrow Transplantation, 19(7), 1013-1020 (2013)
Andreas Lossius et al.
Annals of clinical and translational neurology, 4(10), 756-761 (2017-10-20)
Immunoglobulin gamma (IgG) heavy chain genes are associated with susceptibility to multiple sclerosis (MS) and IgG levels in the cerebrospinal fluid (CSF). However, how these variants are implicated in disease mechanisms remains unknown. Here, we show that proliferating plasmablasts expressing
Recurrence of monoclonal gammopathy associated with donor-derived myelodysplastic syndrome after cord blood stem cell transplantation
Yamazaki R, et al.
Experimental Hematology, 39(12), 1119-1123 (2011)
Virginie Martin et al.
Veterinary research, 45, 69-69 (2014-06-27)
Control of canine leishmaniasis is an important objective for the benefit of dogs living in or visiting endemic areas and for public health because of the zoonotic nature of this disease. Resistance or susceptibility to developing canine leishmaniasis after exposure
Rie Yamazaki et al.
Experimental hematology, 39(12), 1119-1123 (2011-09-14)
Myelodysplastic syndrome (MDS) is known to be associated with functional abnormalities of B cells, including hypergammaglobulinemia and monoclonal gammopathy (MG). However, the pathogenesis of these immunological disorders has not been clarified. We report a patient who developed donor-derived MDS followed

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