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I4777

Sigma-Aldrich

Interferon-γ from mouse

≥98% (SDS-PAGE), recombinant, expressed in E. coli, lyophilized powder, suitable for cell culture

Synonym(e):

IFN-γ

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About This Item

MDL-Nummer:
MFCD00131391
UNSPSC-Code:
12352202
NACRES:
NA.32

Biologische Quelle

mouse

Qualitätsniveau

200

Rekombinant

expressed in E. coli

Assay

≥98% (SDS-PAGE)

Form

lyophilized powder

Mol-Gew.

protein 15.6 kDa

Verpackung

pkg of 0.1 mg

Methode(n)

cell culture | mammalian: suitable

Verunreinigungen

endotoxin, tested

Farbe

white

Löslichkeit

water: soluble 1.000 mL, clear, colorless

UniProt-Hinterlegungsnummer

P01580

Lagertemp.

−20°C

Angaben zum Gen

mouse ... Ifng(15978)

Anwendung

Interferon-γ from mouse has been used:
  • for in vitro stimulation of the BMDC (bone marrow derived dendritic cell), BMM (bone marrow-derived macrophages) and CD11c+ (CD11 antigen-like family member C) lung macrophages
  • for stimulation of murine macrophages to induce the production of nitrite and nitrate
  • to check CCAAT/enhancer binding protein β (C/EBPβ)-mediated changes in the expression of prostaglandin synthesis enzymes in neuroinflammation

Biochem./physiol. Wirkung

Ifng (interferon-γ) plays an important role in innate and adaptive immune responses, and helps in defense against bacterial infections, dimorphic yeast and some viral infections.

Physikalische Form

Lyophilized from a 0.2 μm filtered buffered solution. Package size based on protein content.

Hinweis zur Analyse

The biological activity of recombinant mouse IFN-γ is measured by its ability to inhibit the proliferation of murine WEHI-279 cells.

Lagerklassenschlüssel

11 - Combustible Solids

WGK

WGK 3

Flammpunkt (°F)

Not applicable

Flammpunkt (°C)

Not applicable

Persönliche Schutzausrüstung

Eyeshields, Gloves, type N95 (US)

Analysenzertifikate (COA)

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Sergio Arias-Negrete et al.
Analytical biochemistry, 328(1), 14-21 (2004-04-15)
Preparation of a nitrate reductase lysate of Escherichia coli MC1061 to measure nitrate and nitrite in biologic fluids is described. To obtain the crude bacterial lysate containing nitrate reductase activity, E. coli MC1061 was subjected to 16-20 freeze-thawing cycles, from
S N Vogel et al.
Infection and immunity, 38(2), 681-685 (1982-11-01)
Silica has been used for many years as an agent which selectively alters macrophage functions and, as such, has been used to assess the role of macrophages in the immune response to a variety of microbial and chemically defined agents.
P W Gray et al.
Proceedings of the National Academy of Sciences of the United States of America, 80(19), 5842-5846 (1983-10-01)
The murine immune interferon (IFN-gamma) gene was cloned and expressed under control of the simian virus 40 early promoter in the monkey COS-1 cell line. A protein is secreted from these cells having the biological, antigenic, and biochemical characteristics of
Marta Pulido-Salgado et al.
Scientific reports, 8(1), 16096-16096 (2018-11-02)
Microglia, the main resident immune cells in the CNS, are thought to participate in the pathogenesis of various neurological disorders. LPS and LPS + IFNγ are stimuli that are widely used to activate microglia. However, the transcriptomic profiles of microglia treated with
Andre Heinen et al.
Molecular therapy : the journal of the American Society of Gene Therapy, 27(1), 46-58 (2018-12-12)
Insulin-like growth factor 1 (IGF1) is an anabolic hormone that controls the growth and metabolism of many cell types. However, IGF1 also mediates cardio-protective effects after acute myocardial infarction (AMI), but the underlying mechanisms and cellular targets are not fully
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