H1753

Hydralazin -hydrochlorid

• Synonym(e): 1-Hydrazinophthalazin -hydrochlorid
• Empirische Formel (Hill-System): C₈H₈N₄ · HCl
• CAS-Nummer: 304-20-1
• Molekulargewicht: 196.64
• EG-Nummer: 206-151-0
• MDL-Nummer: MFCD00135998
• UNSPSC-Code: 12352200
• PubChem Substanz-ID: 24278461
• NACRES: NA.77

Eigenschaften

• Biologische Quelle: synthetic (organic)
• Qualitätsniveau: 100
• Assay: ≥99% (TLC)
• Form: powder
• mp (Schmelzpunkt): 273 °C
• Löslichkeit: water: 50 mg/mL
• SMILES String: Cl[H].N\N=C1/N=NC=C2C=CC=CC12
• InChI: 1S/C8H8N4.ClH/c9-11-8-7-4-2-1-3-6(7)5-10-12-8;/h1-5,7H,9H2;1H/b11-8-;
• InChIKey: SECXUXOCDLQOBI-MKFZHGHUSA-N
• Angaben zum Gen: human ... MAOA(4128) , MAOB(4129)

Beschreibung

Anwendung

Hydralazine hydrochloride has been used:

• as a vasodilator to study its effects on hypertension in T-cell frequencies in juvenile rats
• as a semicarbazide-sensitive amine oxidase (SSAO) inhibitor to study its effects on myocardial ischemia-reperfusion (I/R) injury
• as a vasodilator to study its effects on insulin secretion and glucose tolerance

Biochem./physiol. Wirkung

Hydralazine hydrochloride has therapeutic effects against heart failure and high blood pressure.

Inhibits DNA methyltransferase and modulates epigenetic regulation of gene expression. Non-selective MAO-A/B inhibitor; antihypertensive; semicarbazide-sensitive amine oxidase inhibitor.

Leistungsmerkmale und Vorteile

This compound is featured on the Dopamine and Norepinephrine Metabolism page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.

Sicherheitshinweise

• Piktogramme: GHS06
• Signalwort: Danger
• H-Sätze: H301,H315,H319,H335
• P-Sätze: P301 + P310 + P330 - P302 + P352 - P305 + P351 + P338
• Gefahreneinstufungen: Acute Tox. 3 Oral - Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3
• Zielorgane: Respiratory system
• Lagerklassenschlüssel: 6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects
• WGK: WGK 3
• Flammpunkt (°F): Not applicable
• Flammpunkt (°C): Not applicable
• Persönliche Schutzausrüstung: dust mask type N95 (US), Eyeshields, Faceshields, Gloves