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GW20072F

Sigma-Aldrich

Anti-C1QA antibody produced in chicken

affinity isolated antibody, buffered aqueous solution

Synonym(e):

Anti-Complement C1q subcomponent subunit A

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About This Item

UNSPSC-Code:
12352203
NACRES:
NA.41

Biologische Quelle

chicken

Konjugat

unconjugated

Antikörperform

affinity isolated antibody

Antikörper-Produkttyp

primary antibodies

Klon

polyclonal

Form

buffered aqueous solution

Speziesreaktivität

human

Hersteller/Markenname

Genway 15-288-20072F

Methode(n)

indirect ELISA: suitable
western blot: suitable

NCBI-Hinterlegungsnummer

NP_057075.1

UniProt-Hinterlegungsnummer

P02745

Versandbedingung

wet ice

Lagertemp.

−20°C

Posttranslationale Modifikation Target

unmodified

Angaben zum Gen

human ... C1QA(712)

Immunogen

Complement C1q subcomponent subunit A native protein.
Immunogen Sequence: GI # 7705753, sequence 1-245

Anwendung

Anti-C1QA antibody produced in chicken is suitable for indirect ELISA and western blotting analysis at a dilution of 1:500, for tissue or cell staining at a dilution of 1:200.

Biochem./physiol. Wirkung

Complement C1q subcomponent subunit A is a protein encoded by the C1QA gene in humans. Anti-C1q antibodies are found to be pathogenic in the target organ damage of many autoimmune diseases, by facilitating C1q deposition and enhancing complement activation through classical pathway. It is also found to be associated with glomerular basement membrane (GBM) disease and in the pathogenesis of lupus. C1q deficiency leads to the development of autoimmune pathology throughout the life. C1q-binding protein participates in C1q-mediated chemotaxis of blood immune cells.

Physikalische Form

Solution in phosphate buffered saline containing 0.02% sodium azide.

Haftungsausschluss

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

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Lagerklassenschlüssel

10 - Combustible liquids

WGK

WGK 1

Flammpunkt (°F)

Not applicable

Flammpunkt (°C)

Not applicable

Persönliche Schutzausrüstung

Eyeshields, Gloves, multi-purpose combination respirator cartridge (US)

Analysenzertifikate (COA)

Suchen Sie nach Analysenzertifikate (COA), indem Sie die Lot-/Chargennummer des Produkts eingeben. Lot- und Chargennummern sind auf dem Produktetikett hinter den Wörtern ‘Lot’ oder ‘Batch’ (Lot oder Charge) zu finden.

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Die Dokumentenbibliothek aufrufen

Hend Jlajla et al.
Immunobiology, 219(3), 241-246 (2013-12-18)
Hereditary C1q deficiency (C1qD) is the most penetrant genetic factor predisposing to the development of lupus pathology with more than 93% of C1q deficient patients developing this autoimmune pathology throughout their life. It is a rare autosomal recessive deficiency, with
Muriel Tahtouh et al.
Journal of neuroinflammation, 9, 37-37 (2012-02-24)
In invertebrates, the medicinal leech is considered to be an interesting and appropriate model to study neuroimmune mechanisms. Indeed, this non-vertebrate animal can restore normal function of its central nervous system (CNS) after injury. Microglia accumulation at the damage site
B Namjou et al.
Lupus, 21(10), 1113-1118 (2012-04-05)
Homozygous C1q deficiency is an extremely rare condition and strongly associated with systemic lupus erythematosus. To assess and characterize C1q deficiency in an African-American lupus pedigree, C1q genomic region was evaluated in the lupus cases and family members. Genomic DNA
Shui-Yi Hu et al.
BMC immunology, 14, 42-42 (2013-09-24)
Anti-glomerular basement membrane (GBM) disease is a well-known antibody-induced autoimmune disease. A few patients have glomerular C1q deposition, but it is usually absent on renal histopathology. The role of C1q deposition in kidney injury is unclear. Recently, anti-C1q antibodies are

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