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G8032
Gelsolin from bovine plasma
≥95% (SDS-PAGE), lyophilized powder
Anmeldenzur Ansicht organisationsspezifischer und vertraglich vereinbarter Preise
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About This Item
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Assay
≥95% (SDS-PAGE)
Form
lyophilized powder
Spezifische Aktivität
20-100 units/mg protein
Mol-Gew.
74 kDa
Zusammensetzung
Protein, ≤10%
Löslichkeit
soluble 10 imidazole mg/mL
UniProt-Hinterlegungsnummer
Lagertemp.
−20°C
Angaben zum Gen
cow ... GSN(280810)
Anwendung
Gelsolin from bovine plasma was used in actin assembly assays.
Biochem./physiol. Wirkung
Gelsolin is an actin-binding protein that regulates the assembly and disassembly of actin filaments.
Gelsolin is an actin-severing protein found in mammalian cells and blood plasma. Exhibits tumor suppressor activity in several cancer cell lines and in nude mice.
Verpackung
Package size based on protein content
Einheitendefinition
One unit will reduce viscosity difference between actin solution and buffer by 50% in a 1 mL mixture containing 1-2mg F-actin, 0.15 M KCl, 20 mM Tris, pH 7.6, 0.2 mM CaCl2, 0.2 mM ATP, and 1 mM DTT at 28 °C.
Physikalische Form
Lyophilized powder containing NaCl, Tris buffer salt, and EGTA
Signalwort
Warning
H-Sätze
Gefahreneinstufungen
Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3
Zielorgane
Respiratory system
Lagerklassenschlüssel
11 - Combustible Solids
WGK
WGK 3
Flammpunkt (°F)
Not applicable
Flammpunkt (°C)
Not applicable
Persönliche Schutzausrüstung
dust mask type N95 (US), Eyeshields, Gloves
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Markus Ganter et al.
Molecular microbiology, 74(6), 1356-1367 (2009-08-18)
Summary Successful malaria transmission from the mosquito vector to the mammalian host depends crucially on active sporozoite motility. Sporozoite locomotion and host cell invasion are driven by the parasite's own actin/myosin motor. A unique feature of this motor machinery is
Takehito Uruno et al.
The Journal of biological chemistry, 281(15), 10635-10650 (2006-01-26)
Acanthamoeba CARMIL was previously shown to co-purify with capping protein (CP) and to bind pure CP. Here we show that this interaction inhibits the barbed end-capping activity of CP. Even more strikingly, this interaction drives the uncapping of actin filaments
R C Koya et al.
The Journal of biological chemistry, 275(20), 15343-15349 (2000-05-16)
Apoptotic cell death, characterized by chromatin condensation, nuclear fragmentation, cell membrane blebbing, and apoptotic body formation, is also accompanied by typical mitochondrial changes. The latter includes enhanced membrane permeability, fall in mitochondrial membrane potential (Deltapsi(m)) and release of cytochrome c
Gelsolin, a multifunctional actin regulatory protein.
H Q Sun et al.
The Journal of biological chemistry, 274(47), 33179-33182 (1999-11-24)
Nikolaos Parisis et al.
The EMBO journal, 36(21), 3212-3231 (2017-10-07)
Nuclear actin regulates transcriptional programmes in a manner dependent on its levels and polymerisation state. This dynamics is determined by the balance of nucleocytoplasmic shuttling, formin- and redox-dependent filament polymerisation. Here, using
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