F7807

Prostaglandin F Synthase human

recombinant, expressed in E. coli, ≥90% (SDS-PAGE)

• Synonym(e): 17-beta-hydroxysteroid dehydrogenase type 5, AKR1C3, aldo-keto reductase family 1 member C3, indanol dehydrogenase
• CAS-Nummer: 55976-95-9
• EC-Nummer: 1.1.1.188 (BRENDA, IUBMB)
• UNSPSC-Code: 12352204
• NACRES: NA.54

Eigenschaften

• Rekombinant: expressed in E. coli
• Qualitätsniveau: 200
• Beschreibung: contains a C-terminal hexahistidine tag
• Assay: ≥90% (SDS-PAGE)
• Form: liquid
• Spezifische Aktivität: ≥0.4 μmol/mg protein
• Mol-Gew.: ~37 kDa
• NCBI-Hinterlegungsnummer: NP_003730
• Versandbedingung: dry ice
• Lagertemp.: −70°C
• Angaben zum Gen: human ... AKR1C3(8644)

Beschreibung

Anwendung

Prostaglandin F synthase (PGF synthase) is a member of the aldo-keto reductase superfamily of proteins which catalyze the conversion of aldehydes and ketones to thier corresponding alcohols. Prostaglandin F synthase is used in cancer research since it is upregulated in many cancers such as breast and prostate cancer. PGF synthase is also used to study kidney and renal cell carcinoma .

Biochem./physiol. Wirkung

PGF synthase catalyzes the conversions of 4-androstene-3,17-dione to testosterone, estrone to 17β-estradiol, prostaglandin H2 to PGF2α, and PGD2 to 9α,11β-PGF2. Prostaglandin (PG) F2 is synthesized via three pathways .

Einheitendefinition

One unit is defined as the amount of enzyme required to produce 1 μmol of NADP per minute at 37°C in 50 mM KPO₄ pH 7.2 containing 250 μM NADPH and 25 μM 9,10-phenanthrenequinone

Sicherheitshinweise

• Lagerklassenschlüssel: 10 - Combustible liquids
• WGK: WGK 1
• Flammpunkt (°F): Not applicable
• Flammpunkt (°C): Not applicable