F6557
FYN A, active, GST tagged human
PRECISIO® Kinase, recombinant, expressed in baculovirus infected Sf9 cells, ≥70% (SDS-PAGE), buffered aqueous glycerol solution
Synonym(e):
MGC45350, SLK, SYN
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Alle Fotos(1)
About This Item
UNSPSC-Code:
12352200
NACRES:
NA.32
Empfohlene Produkte
Rekombinant
expressed in baculovirus infected Sf9 cells
Qualitätsniveau
Produktlinie
PRECISIO® Kinase
Assay
≥70% (SDS-PAGE)
Form
buffered aqueous glycerol solution
Spezifische Aktivität
141-195 nmol/min·mg
Mol-Gew.
~85 kDa
UniProt-Hinterlegungsnummer
Versandbedingung
dry ice
Lagertemp.
−70°C
Angaben zum Gen
human ... FYN(2534)
Allgemeine Beschreibung
FYN proto-oncogene is a member of the Src family of tyrosine kinases, and has a molecular weight of 59kDa. Post-synthesis this protein is N-myristoylated on cytoplasmic polysomes. It is palmitoylated after it has been targeted to the cell membrane. This protein can also be acylated twice, which leads to its clustering into microdomains in the caveolae-like membrane.
Biochem./physiol. Wirkung
FYN proto-oncogene interacts with multiple signaling molecules, and is involved in T-cell receptor (TCR) signaling, brain function control, along with the control of adhesion-mediated signaling. It might have potential as a target for autoimmune disorders and alcohol addiction. It is also implicated in melanoma tumorigenes in a immunoglobulin (Ig)E-mediated manner. In mesenchymal stem cells, it controls RhoA and adipogenesis, through its interaction with mTORC2 (mammalian target of rapamycin complex 2).
Physikalische Form
Supplied in 50 mM Tris-HCl, pH 7.5, with 150 mM NaCl, 0.25 mM DTT, 0.1 mM EGTA, 0.1 mM EDTA, 0.1 mM PMSF, and 25% glycerol.
Rechtliche Hinweise
PRECISIO is a registered trademark of Merck KGaA, Darmstadt, Germany
Lagerklassenschlüssel
10 - Combustible liquids
WGK
WGK 1
Flammpunkt (°F)
Not applicable
Flammpunkt (°C)
Not applicable
Analysenzertifikate (COA)
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William R Thompson et al.
Stem cells (Dayton, Ohio), 31(11), 2528-2537 (2013-07-10)
Mechanical strain provides an anti-adipogenic, pro-osteogenic stimulus to mesenchymal stem cells (MSC) through generating intracellular signals and via cytoskeletal restructuring. Recently, mTORC2 has been shown to be a novel mechanical target critical for the anti-adipogenic signal leading to preservation of
Guillermina Yanek Jiménez-Andrade et al.
Journal of hematology & oncology, 6, 56-56 (2013-08-07)
High concentrations of plasmatic IgE have been related to distinct systemic inflammatory conditions that frequently predispose individuals to hypersensitivity reactions. Although effects of IgE have been suggested to relay on the low-intensity activation of distinct effector elements of the immune
Kechen Ban et al.
Blood, 111(5), 2904-2908 (2008-01-09)
Chronic myelogenous leukemia (CML) invariably progresses to blast crisis, which represents the most proliferative phase of the disease. The BCR-ABL1 oncogene stimulates growth and survival pathways by phosphorylating numerous substrates, including various Src family members. Here we describe up-regulation, in
M D Resh
The international journal of biochemistry & cell biology, 30(11), 1159-1162 (1998-12-05)
Fyn is a 59 kDa member of the Src family of tyrosine kinases. The protein is synthesized and N-myristoylated on cytosolic polysomes and then rapidly targeted to the plasma membrane, where it is palmitoylated. Dually acylated Fyn clusters in caveolae-like
Hyang-Sook Hoe et al.
The Journal of biological chemistry, 283(10), 6288-6299 (2007-12-20)
Dab1 is an intracellular adaptor protein that interacts with amyloid precursor protein (APP) and apoE receptor 2 (apoEr2), increases their levels on the cell surface, and increases their cleavage by alpha-secretases. To investigate the mechanism underlying these alterations in processing
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