F5013

5-Fluororotsäure Hydrat

≥98%

• Synonym(e): 2,6-Dihydroxy-5-fluor-pyrimidin-4-carbonsäure, 5-Fluor-uracil-4-carbonsäure
• Empirische Formel (Hill-System): C₅H₃FN₂O₄ · xH₂O
• CAS-Nummer: 207291-81-4
• Molekulargewicht: 174.09 (anhydrous basis)
• EG-Nummer: 211-876-0
• MDL-Nummer: MFCD00150658
• UNSPSC-Code: 12352204
• PubChem Substanz-ID: 24894877
• NACRES: NA.32

Eigenschaften

• Biologische Quelle: synthetic
• Assay: ≥98%
• Form: powder
• Methode(n): cell culture | plant: suitable
• mp (Schmelzpunkt): 278 °C (dec.) (lit.)
• Löslichkeit: 4 M NH₄OH: 50 mg/mL, clear, colorless to light yellow
• Lagertemp.: −20°C
• SMILES String: OC(C(NC(N1)=O)=C(F)C1=O)=O.[H]O[H]
• InChI: 1S/C5H3FN2O4.H2O/c6-1-2(4(10)11)7-5(12)8-3(1)9;/h(H,10,11)(H2,7,8,9,12);1H2
• InChIKey: LODRRYMGPWQCTR-UHFFFAOYSA-N

Beschreibung

Anwendung

5-Fluoroorotic acid hydrate has also been used as a counter-selection agent to screen L. lactis (multi) peptidase knockout mutants and C. albicans. It has been used in synthesis of 5-fluoroorotidine 5′-monophosphate (FOMP).

Useful in the selection of orotidine-5′-phosphate decarboxylase mutants of Saccharomyces cerevisiae.

Biochem./physiol. Wirkung

5-Fluoroorotic acid is a selective inhibitor of rRNA synthesis in mammals.

Sicherheitshinweise

• Piktogramme: GHS07
• Signalwort: Warning
• H-Sätze: H302,H315,H319,H335
• P-Sätze: P261 - P264 - P271 - P301 + P312 - P302 + P352 - P305 + P351 + P338
• Gefahreneinstufungen: Acute Tox. 4 Oral - Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3
• Zielorgane: Respiratory system
• Lagerklassenschlüssel: 11 - Combustible Solids
• WGK: WGK 3
• Flammpunkt (°F): Not applicable
• Flammpunkt (°C): Not applicable
• Persönliche Schutzausrüstung: dust mask type N95 (US), Eyeshields, Gloves