F2302

Fractalkine Peptide

>97% (SDS-PAGE), lyophilized powder, mouse recombinant, expressed in E. coli

• Synonym(e): CX3CL-1, Neurotactin
• MDL-Nummer: MFCD01635336
• UNSPSC-Code: 51111800
• NACRES: NA.32

Eigenschaften

• product name: Fractalkine, Chemokine Domain from mouse, >97% (SDS-PAGE), recombinant, expressed in E. coli, lyophilized powder
• Biologische Quelle: mouse
• Qualitätsniveau: 100
• Rekombinant: expressed in E. coli
• Assay: >97% (SDS-PAGE)
• Form: lyophilized powder
• Wirksamkeit: 0.3-3 μg/mL
• Mol-Gew.: calculated mol wt ~9.5 kDa
• Verpackung: pkg of 25 μg
• Lagerbedingungen: avoid repeated freeze/thaw cycles
• Verunreinigungen: endotoxin, tested
• UniProt-Hinterlegungsnummer: O35188
• Lagertemp.: −20°C
• Angaben zum Gen: mouse ... Cx3cl1(20312)

Beschreibung

Allgemeine Beschreibung

CX3CL1 (chemokine (C-X3-C motif) ligand 1) or fractalkine is a membrane protein, which is the only member of CXC3 family. Its chemokine domain (CKD) anchors it to the cell membrane through its mucin-like stalk. It acts as a ligand for the G-protein coupled receptor CX3CR1, which is found on smooth muscle cells, T-cells, natural killer (NK) cells and monocytes. Fractalkine is expressed on epithelial, endothelial and smooth muscle cells and neurons.

Biochem./physiol. Wirkung

CX3CL1 (chemokine (C-X3-C motif) ligand 1) or fractalkine, along with CX3CR1 is involved in various disorders such as atherosclerosis, multiple sclerosis, neuropathic pain and rheumatic disorders. It facilitates the proliferation and survival of primary human vascular smooth muscle cells in an epidermal growth factor receptor (EGR)-dependent manner. It plays an essential role in cell survival and promotes the survival of cells such as monocytes, T-cells and microglia. In humans, it is thought to be involved in atherogenesis, and thus, might have potential as a target in treatment of cardiovascular disease. In patients with sickle cell disease (SCD), the serum levels of this chemokine is increased, thus implicating it in the pathogenesis of inflammation associated with SCD.

Leukocyte chemoattractant protein and member of the chemokine superfamily possessing a CX₃C motif. Mouse fractalkine is chemotactic for neutrophils and T-lymphocytes but not monocytes.

Physikalische Form

Lyophilized from a 0.2 μm filtered solution in 30% acetonitrile and 0.1% TFA containing 1.25 mg bovine serum albumin.

Hinweis zur Analyse

The biological activity is measured by its ability to chemoattract freshly isolated peripheral blood lymphocytes.

Sicherheitshinweise

• Piktogramme: GHS05
• Signalwort: Danger
• H-Sätze: H315,H318
• P-Sätze: P280 - P305 + P351 + P338
• Gefahreneinstufungen: Eye Dam. 1 - Skin Irrit. 2
• Lagerklassenschlüssel: 11 - Combustible Solids
• WGK: WGK 3
• Flammpunkt (°F): Not applicable
• Flammpunkt (°C): Not applicable