E3539

Proteinase 3 from human leukocytes

≥95% (PAGE)

• Synonym(e): AGP7, Myeloblastin, P29B, PR-3, PR3 Ag
• EC-Nummer: 3.4.21.76 (BRENDA, IUBMB)
• MDL-Nummer: MFCD03458212
• UNSPSC-Code: 12352204
• NACRES: NA.54

Eigenschaften

• Assay: ≥95% (PAGE)
• Form: buffered aqueous solution
• UniProt-Hinterlegungsnummer: P24158
• Lagertemp.: −20°C
• Angaben zum Gen: human ... PRTN3(5657)

Beschreibung

Allgemeine Beschreibung

Proteinase 3 is found in high concentration in the primary granules of myeloid leukemia blasts.⁴

Anwendung

Proteinase 3 has been shown to be important in the pathogenesis of human emphysema.¹ It has also been used in a study to investigate the liberation of the antibacterial and cytotoxic peptide LL-37 by cleavage of human cathelicidin hCAP-183.²

Biochem./physiol. Wirkung

Proteinase 3 (PR-3) is a serine protease expressed in the granules of neutrophils and monocytes. Also known as myeloblastin and p29b, it degrades elastin and is associated with myeloid leukemia and Wegener′s granulomatosis.³

Used for the detection of anti-PR3 auto-antibodies in immunoassays.

Physikalische Form

Solution in 50 mM sodium acetate (pH 5) with 600 mM sodium chloride

Sicherheitshinweise

• Lagerklassenschlüssel: 12 - Non Combustible Liquids
• WGK: WGK 1
• Flammpunkt (°F): Not applicable
• Flammpunkt (°C): Not applicable