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E1532

Sigma-Aldrich

Monoclonal Anti-E2F6 antibody produced in mouse

~1.0 mg/mL, clone TFE61, purified immunoglobulin, buffered aqueous solution

Synonym(e):

Anti-E2F transcription factor 6, Anti-E2F-6

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About This Item

UNSPSC-Code:
12352203
NACRES:
NA.41

Biologische Quelle

mouse

Konjugat

unconjugated

Antikörperform

purified immunoglobulin

Antikörper-Produkttyp

primary antibodies

Klon

TFE61, monoclonal

Form

buffered aqueous solution

Mol-Gew.

antigen ~35 kDa

Speziesreaktivität

human

Konzentration

~1.0 mg/mL

Methode(n)

immunocytochemistry: suitable
indirect ELISA: suitable
western blot: 2-4 μg/mL using HeLa nuclear cell extract

Isotyp

IgG1

UniProt-Hinterlegungsnummer

O75461

Versandbedingung

dry ice

Lagertemp.

−20°C

Posttranslationale Modifikation Target

unmodified

Angaben zum Gen

human ... E2F6(1876)

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Allgemeine Beschreibung

E2F6 transcription factor belongs to the third class of E2Fs. The E2F transcription factors are a family of genes that play critical roles in regulation of cellular proliferation and differentiation.

Immunogen

recombinant human E2F6 protein

Anwendung

Monoclonal Anti-E2F6 antibody produced in mouse is suitable for immunocytochemistry and indirect ELISA. It is also suitable for western blotting at a working concentration of 2-4μg/mL using HeLa nuclear cell extract.

Biochem./physiol. Wirkung

The third class of E2Fs lacks both the retinoblastoma protein binding and transcriptional activation domain, and is an active repressor of transcription. The activity of E2F6 is mediated through its recruitment of polycomb transcriptional repressor complexes in a histone methylation independent manner. E2F6 associates with E2F target genes that are activated at G1/S phase. Its repression activity during the S-phase distinguishes G1/S and G2/M transcription during cell cycle. It may be involved in various cancerous processes.

Physikalische Form

Solution in 0.01 M phosphate buffered saline, pH 7.4, containing 15 mM sodium azide.

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Lagerklassenschlüssel

10 - Combustible liquids

Flammpunkt (°F)

Not applicable

Flammpunkt (°C)

Not applicable

Persönliche Schutzausrüstung

Eyeshields, Gloves, multi-purpose combination respirator cartridge (US)

Analysenzertifikate (COA)

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Gwen MacDonald et al.
Breast cancer research : BCR, 9(4), R49-R49 (2007-08-01)
Decreased transcription of the BRCA1 gene has previously been observed to occur in sporadic breast tumours, making elucidation of the mechanisms regulating the expression of this gene important for our understanding of the etiology of the disease. Transcriptional elements involved
Phillip J Iaquinta et al.
Current opinion in cell biology, 19(6), 649-657 (2007-11-23)
The E2F transcription factors are critical regulators of genes required for appropriate progression through the cell cycle, and in special circumstances they can also promote the expression of another class of genes that function in the apoptotic program. Since E2Fs
J M Trimarchi et al.
Proceedings of the National Academy of Sciences of the United States of America, 95(6), 2850-2855 (1998-04-18)
The E2F family of proteins is required to establish the correct cell-cycle-dependent transcription of genes that direct the process of cell division. All previously identified E2F proteins can act in a similar manner; depending on whether or not they are
Paloma H Giangrande et al.
Genes & development, 18(23), 2941-2951 (2004-12-03)
E2F transcription factors play a critical role in the control of cell cycle progression, regulating the expression of genes involved in DNA replication, DNA repair, mitosis, and cell fate. This involves both positive-acting and negative-acting E2F proteins, the latter group
S Gaubatz et al.
Proceedings of the National Academy of Sciences of the United States of America, 95(16), 9190-9195 (1998-08-05)
E2F transcription factors play an important role in the regulation of cell cycle progression. We report here the cloning and characterization of an additional member of this family, E2F-6. E2F-6 lacks pocket protein binding and transactivation domains, and it is
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