E1530

Anti-phospho-Epidermal Growth Factor Receptor (pTyr¹⁰⁸⁶) antibody produced in rabbit

affinity isolated antibody, buffered aqueous glycerol solution

• Synonym(e): Anti-phospho-EGFR (pTyr¹⁰⁸⁶)
• MDL-Nummer: MFCD03845326
• UNSPSC-Code: 51111800
• NACRES: NA.41

Eigenschaften

• Biologische Quelle: rabbit
• Qualitätsniveau: 200
• Konjugat: unconjugated
• Antikörperform: affinity isolated antibody
• Antikörper-Produkttyp: primary antibodies
• Klon: polyclonal
• Form: buffered aqueous glycerol solution
• Mol-Gew.: antigen ~185 kDa
• Speziesreaktivität: human, mouse, rat
• Methode(n): western blot: 1:1,000
• UniProt-Hinterlegungsnummer: P00533
• Versandbedingung: wet ice
• Lagertemp.: −20°C
• Posttranslationale Modifikation Target: phosphorylation (pTyr1086)
• Angaben zum Gen: human ... EGFR(1956) ; mouse ... Egfr(13649)

Beschreibung

Immunogen

synthetic phosphopeptide derived from the region of EGFR that contains tyrosine 1086.

Biochem./physiol. Wirkung

EGFR is a transmembrane glycoprotein that binds to the EGF family. It is a pivotal regulator of cell proliferation, growth, differentiation and DNA repair after radiation-induced damage. Mutations in the gene encoding EGFR are associated with a number of malignancies including lung cancer and colorectal cancer. Tyr1086 is a minor autophosphorylation site and enables the internalization of the receptor.

Physikalische Form

Solution in Dulbecco′s phosphate buffered saline without Mg²⁺ and Ca²⁺, pH 7.3 with 50% glycerol, 1 mg/mL BSA (protease and IgG free) and 0.05% sodium azide.

Haftungsausschluss

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

Sicherheitshinweise

• Lagerklassenschlüssel: 10 - Combustible liquids