D9160

1-Desoxymannojirimycin -hydrochlorid

• Synonym(e): 1,5-Dideoxy-1,5-imino-D-mannitol -hydrochlorid
• Empirische Formel (Hill-System): C₆H₁₃NO₄ · HCl
• CAS-Nummer: 73465-43-7
• Molekulargewicht: 199.63
• MDL-Nummer: MFCD00083611
• UNSPSC-Code: 51102829
• PubChem Substanz-ID: 24894265
• NACRES: NA.76

Eigenschaften

• Form: powder
• Qualitätsniveau: 200
• Farbe: white to off-white
• Löslichkeit: H₂O: 10 mg/mL
• Wirkungsspektrum von Antibiotika: viruses
• Wirkungsweise: enzyme | inhibits
• Lagertemp.: 2-8°C
• SMILES String: Cl.OC[C@H]1NC[C@@H](O)[C@@H](O)[C@@H]1O
• InChI: 1S/C6H13NO4.ClH/c8-2-3-5(10)6(11)4(9)1-7-3;/h3-11H,1-2H2;1H/t3-,4-,5-,6-;/m1./s1
• InChIKey: ZJIHMALTJRDNQI-MVNLRXSJSA-N

Beschreibung

Allgemeine Beschreibung

Chemical structure: glucosamine

Anwendung

1-Deoxymannojirimycin (DMM) hydrochloride is an inhibitor of N-linked glycosylation and has antiviral activity. Derivatives of deoxymannojirimycin may have anti-HIV activity. It has been used for treatment of T lymphocytes and to study it′s effect on allogeneic cytotoxic T lymphocytes (CTL). It is used for studies on Golgi-mediated glycoprotein processing.

Biochem./physiol. Wirkung

1-Deoxymannojirimycin is a mannosidase I inhibitor, alters cell-surface complex carbohydrate structure as assayed by PHA-L binding, and increases high mannose structures as indicated by the increased Con-A binding.

Selectively inhibits Golgi associated α(1→2) mannosidase and for studies on Golgi-mediated glycoprotein processing.

Sicherheitshinweise

• Piktogramme: GHS07
• Signalwort: Warning
• H-Sätze: H302 + H312 + H332
• P-Sätze: P261 - P264 - P280 - P301 + P312 - P302 + P352 + P312 - P304 + P340 + P312
• Gefahreneinstufungen: Acute Tox. 4 Dermal - Acute Tox. 4 Inhalation - Acute Tox. 4 Oral
• Lagerklassenschlüssel: 11 - Combustible Solids
• WGK: WGK 3
• Persönliche Schutzausrüstung: dust mask type N95 (US), Eyeshields, Gloves