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D7017

Sigma-Aldrich

Dynorphin A Porcine Fragment 1-13

≥97% (HPLC)

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About This Item

Empirische Formel (Hill-System):
C75H126N24O15
CAS-Nummer:
72957-38-1
Molekulargewicht:
1603.95
MDL-Nummer:
MFCD00076366
UNSPSC-Code:
12352202
PubChem Substanz-ID:
24894071
NACRES:
NA.32

Qualitätsniveau

200

Assay

≥97% (HPLC)

Form

powder

Zusammensetzung

Peptide content, ≥50%

UniProt-Hinterlegungsnummer

P01214

Lagertemp.

−20°C

SMILES String

CCC(C)C(NC(=O)C(CCCNC(N)=N)NC(=O)C(CCCNC(N)=N)NC(=O)C(CC(C)C)NC(=O)C(Cc1ccccc1)NC(=O)CNC(=O)CNC(=O)C(N)Cc2ccc(O)cc2)C(=O)NC(CCCNC(N)=N)C(=O)N3CCCC3C(=O)NC(CCCCN)C(=O)NC(CC(C)C)C(=O)NC(CCCCN)C(O)=O

InChI

1S/C75H126N24O15/c1-7-45(6)61(70(111)94-53(25-17-35-87-75(83)84)71(112)99-36-18-26-58(99)69(110)93-50(21-11-13-31-76)64(105)96-56(38-44(4)5)67(108)95-54(72(113)114)22-12-14-32-77)98-65(106)52(24-16-34-86-74(81)82)91-63(104)51(23-15-33-85-73(79)80)92-66(107)55(37-43(2)3)97-68(109)57(40-46-19-9-8-10-20-46)90-60(102)42-88-59(101)41-89-62(103)49(78)39-47-27-29-48(100)30-28-47/h8-10,19-20,27-30,43-45,49-58,61,100H,7,11-18,21-26,31-42,76-78H2,1-6H3,(H,88,101)(H,89,103)(H,90,102)(H,91,104)(H,92,107)(H,93,110)(H,94,111)(H,95,108)(H,96,105)(H,97,109)(H,98,106)(H,113,114)(H4,79,80,85)(H4,81,82,86)(H4,83,84,87)

InChIKey

OVVIBUHLQIYUEU-UHFFFAOYSA-N

Angaben zum Gen

pig ... PDYN(445529)

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Amino Acid Sequence

Tyr-Gly-Gly-Phe-Leu-Arg-Arg-Ile-Arg-Pro-Lys-Leu-Lys

Anwendung

Dynorphin A Porcine Fragment 1-13 has been used as a test compound in the field asymmetric waveform ion mobility spectrometry coupled to mass spectrometry (FAIMS/IMS/MS).

Biochem./physiol. Wirkung

Dynorphin (Dyn) (1-13), a bioactive product of dynorphin A displays interaction with N-methyl- D-aspartate (NMDA) as well as with opioid receptors. It elevates intracellular calcium [Ca2+]i level and contributes to the loss of neurons affecting neuronal viability.

Lagerklassenschlüssel

11 - Combustible Solids

WGK

WGK 3

Flammpunkt (°F)

Not applicable

Flammpunkt (°C)

Not applicable

Persönliche Schutzausrüstung

Eyeshields, Gloves, type N95 (US)

Analysenzertifikate (COA)

Suchen Sie nach Analysenzertifikate (COA), indem Sie die Lot-/Chargennummer des Produkts eingeben. Lot- und Chargennummern sind auf dem Produktetikett hinter den Wörtern ‘Lot’ oder ‘Batch’ (Lot oder Charge) zu finden.

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Sylvie Tordjman et al.
Behavior genetics, 33(5), 529-536 (2003-10-24)
Previous studies suggest that brain opioid activity decreases aggression in animal models. The main objective of the current study was to examine the possible genetic relationship between intermale aggression and brain levels of enkephalins, endorphins, and dynorphins in 11 inbred
Xin Sun et al.
Life sciences, 78(21), 2516-2522 (2005-12-13)
To investigate the relaxation effect and underlying mechanism of U50,488H (a selective kappa-opioid receptor agonist) in pulmonary artery in the rat. Isolated pulmonary artery ring was perfused and the tension of the vessel was measured. U50,488H relaxed the pulmonary artery
Jing Liang et al.
Neuropharmacology, 58(1), 233-240 (2009-07-15)
Our previous studies have demonstrated that morphine-induced conditioned place preference (CPP) can be inhibited by 2 Hz electroacupuncture (EA). This inhibition can be blocked by either the opioid receptor antagonist naloxone (i.p.) or lesion in the nucleus accumbens (NAc), providing
M Hiramatsu et al.
Methods and findings in experimental and clinical pharmacology, 20(7), 595-599 (1998-11-20)
The role of kappa-opioid receptor agonists on learning and memory is controversial. In this review, the effects of dynorphin A (1-13) and U-50,488H on learning and memory impairments in mice and rats are summarized. Muscarinic cholinergic antagonists and a nicotinic
K F Hauser et al.
Experimental neurology, 160(2), 361-375 (2000-01-05)
Dynorphin A is an endogenous opioid peptide that preferentially activates kappa-opioid receptors and is antinociceptive at physiological concentrations. Levels of dynorphin A and a major metabolite, dynorphin A (1-13), increase significantly following spinal cord trauma and reportedly contribute to neurodegeneration
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