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D6321

Sigma-Aldrich

Droxinostat

≥98% (HPLC)

Synonym(e):

4-(4-Chloro-2-methylphenoxy)-N-hydroxybutanamide

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About This Item

Empirische Formel (Hill-System):
C11H14ClNO3
CAS-Nummer:
99873-43-5
Molekulargewicht:
243.69
MDL-Nummer:
MFCD01326592
UNSPSC-Code:
12352200
PubChem Substanz-ID:
329798826
NACRES:
NA.77

Assay

≥98% (HPLC)

Form

powder

Farbe

white to off-white

Löslichkeit

DMSO: ≥20 mg/mL

Lagertemp.

2-8°C

SMILES String

Cc1cc(Cl)ccc1OCCCC(=O)NO

InChI

1S/C11H14ClNO3/c1-8-7-9(12)4-5-10(8)16-6-2-3-11(14)13-15/h4-5,7,15H,2-3,6H2,1H3,(H,13,14)

InChIKey

JHSXDAWGLCZYSM-UHFFFAOYSA-N

Biochem./physiol. Wirkung

Droxinostat is a selective inhibitor of HDAC3, HDAC6, and HDAC8.

Leistungsmerkmale und Vorteile

This compound is a featured product for Gene Regulation research. Click here to discover more featured Gene Regulation products. Learn more about bioactive small molecules for other areas of research at sigma.com/discover-bsm.

Piktogramme

CorrosionExclamation mark
GHS05,GHS07

Signalwort

Danger

Gefahreneinstufungen

Acute Tox. 4 Oral - Eye Dam. 1 - Skin Irrit. 2 - STOT SE 3

Lagerklassenschlüssel

11 - Combustible Solids

WGK

WGK 3

Flammpunkt (°F)

Not applicable

Flammpunkt (°C)

Not applicable

Hier finden Sie alle aktuellen Versionen:

Analysenzertifikate (COA)

Lot/Batch Number
050M4619

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Die Dokumentenbibliothek aufrufen

Histone Deacetylase 3 Inhibition Overcomes
Azusa Tanimoto et al.
Clinical cancer research : an official journal of the American Association for Cancer Research, 23(12), 3139-3149 (2016-12-18)
Ying Huang et al.
Cellular & molecular biology letters, 23, 34-34 (2018-08-02)
Upregulation of histone acetylation plays a critical role in the dysregulation of transcription. It alters the structure of chromatin, which leads to the onset of cancer. Histone deacetylase inhibitors may therefore be a promising way to limit cancer progression. In
Gera Goverse et al.
Journal of immunology (Baltimore, Md. : 1950), 198(5), 2172-2181 (2017-01-20)
The gastrointestinal tract is continuously exposed to many environmental factors that influence intestinal epithelial cells and the underlying mucosal immune system. In this article, we demonstrate that dietary fiber and short chain fatty acids (SCFAs) induced the expression of the
Di Huang et al.
Nature immunology, 19(10), 1112-1125 (2018-09-19)
Activation-induced cell death (AICD) of T lymphocytes can be exploited by cancers to escape immunological destruction. We demonstrated that tumor-specific cytotoxic T lymphocytes (CTLs) and type 1 helper T (TH1) cells, rather than type 2 helper T cells and regulatory
Dominik Stammler et al.
Journal of immunology (Baltimore, Md. : 1950), 195(11), 5421-5431 (2015-11-01)
Histone deacetylase (HDAC) inhibitors (HDACi) are clinically approved anticancer drugs that have important immune-modulatory properties. We report the surprising finding that HDACi promote LPS-induced IL-1β processing and secretion in human and murine dendritic cells and murine macrophages. HDACi/LPS-induced IL-1β maturation
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Artikel

Histone Modification and Chromatin Remodeling | Epigenetics

Epigenetic modifications are thought to occur through two key interconnected processes—DNA methylation and the covalent modification of histones.

Unser Team von Wissenschaftlern verfügt über Erfahrung in allen Forschungsbereichen einschließlich Life Science, Materialwissenschaften, chemischer Synthese, Chromatographie, Analytik und vielen mehr..

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