D1445

Anti-DPP4 (61-75) antibody produced in rabbit

IgG fraction of antiserum, buffered aqueous solution

• Synonym(e): Anti-ADABP, Anti-ADCP2, Anti-CD26, Anti-DPPIV, Anti-Dipeptidyl peptidase 4, Anti-TP103
• UNSPSC-Code: 12352203
• NACRES: NA.41

Eigenschaften

• Biologische Quelle: rabbit
• Konjugat: unconjugated
• Antikörperform: IgG fraction of antiserum
• Antikörper-Produkttyp: primary antibodies
• Klon: polyclonal
• Form: buffered aqueous solution
• Mol-Gew.: antigen ~88 kDa
• Speziesreaktivität: human
• Methode(n): western blot: 1:500-1:2,000
• UniProt-Hinterlegungsnummer: P27487
• Versandbedingung: dry ice
• Lagertemp.: −20°C
• Posttranslationale Modifikation Target: unmodified
• Angaben zum Gen: human ... DPP4(1803)

Beschreibung

Immunogen

synthetic peptide corresponding to amino acids 61-75 of human DPP4

Anwendung

Anti-DPP4 antibody produced in rabbit is suitable for western blotting at a working dilution of 1:500-1:2000. Yale Center for High Throughput Cell Biology IF-tested antibodies. Each antibody is tested by immunofluorescence against HUVEC cells using the Yale HTCB IF protocol. To learn more about us and Yale Center for High Throughput Cell Biology partnership, visit sigma.com/htcb-if.

Biochem./physiol. Wirkung

DPP4 is a cell surface glycoprotein receptor involved in the costimulatory signal essential for T-cell receptor (TCR)-mediated T-cell activation. It regulates various physiological processes by cleaving peptides in the circulation, including many chemokines, mitogenic growth factors, neuropeptides and peptide hormones. It removes N-terminal dipeptides sequentially from polypeptides having unsubstituted N-termini with proline as the penultimate residue. It is ubiquitously expressed in epithelial and endothelial cells and plays a role in the migration and invasion of human endothelial cells in collagenous matrices. ADA-DPP4 interaction on the cell surface regulates lymphocyte-epithelial cell adhesion. Dipeptidyl peptidase activity of this protein is inhibited by the binding of Simpson-Golabi-Behmel syndrome causative glypican-3.

Physikalische Form

Solution in 0.01 M phosphate buffered saline, pH 7.4, containing 15 mM sodium azide

Haftungsausschluss

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

Sicherheitshinweise

• Lagerklassenschlüssel: 10 - Combustible liquids
• WGK: WGK 2
• Flammpunkt (°F): Not applicable
• Flammpunkt (°C): Not applicable
• Persönliche Schutzausrüstung: Eyeshields, Gloves, multi-purpose combination respirator cartridge (US)