C8742

CHIC-35

≥97% (chiral, HPLC)

• Synonym(e): (6S)-2-Chloro-5,6,7,8,9,10-hexahydro-cyclohept[b]indole-6-carboxamide, Compound (S)-35
• Empirische Formel (Hill-System): C₁₄H₁₅ClN₂O
• CAS-Nummer: 848193-72-6
• Molekulargewicht: 262.73
• MDL-Nummer: MFCD11045286
• UNSPSC-Code: 12352200
• PubChem Substanz-ID: 329775186
• NACRES: NA.77

Eigenschaften

• Assay: ≥97% (chiral, HPLC)
• Form: solid
• Löslichkeit: DMSO: >10 mg/mL; H₂O: <2 mg/mL
• Lagertemp.: 2-8°C
• SMILES String: ClC1=CC=C(NC2=C3CCCC[C@@H]2C(N)=O)C3=C1
• InChI: 1S/C14H15ClN2O/c15-8-5-6-12-11(7-8)9-3-1-2-4-10(14(16)18)13(9)17-12/h5-7,10,17H,1-4H2,(H2,16,18)/t10-/m0/s1
• InChIKey: ABIVOOWWGYJNLV-JTQLQIEISA-N

Beschreibung

Biochem./physiol. Wirkung

CHIC-35 is cell-permeable, metabolically stable, and very potent inhibitor of SIRT1.

CHIC-35 is cell-permeable, metabolically stable, and very potent inhibitor of SIRT1; IC₅₀ of S-isomer is 60 nM; IC₅₀ of mixed isomers is 124 nM. There is no inhibition of SIRT3 or HDAC. The IC₅₀ for SIRT2 is 2.77 μM. Sirtuins are protein deacetylases, which represent a new class of histone deacetylases (HDAC) involved in gene silencing. SIRT modulators are potential therapeutics for cancer, diabetes, muscle differentiation, heart failure, neurodegeneration, and aging.

Leistungsmerkmale und Vorteile

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Sicherheitshinweise

• Lagerklassenschlüssel: 11 - Combustible Solids
• WGK: WGK 3
• Persönliche Schutzausrüstung: dust mask type N95 (US), Eyeshields, Faceshields, Gloves