C6995

Anti-COMT (N-terminal) antibody produced in rabbit

IgG fraction of antiserum, buffered aqueous solution

• Synonym(e): Anti-Catechol-O-methyltransferase
• UNSPSC-Code: 12352203
• NACRES: NA.41

Eigenschaften

• Biologische Quelle: rabbit
• Konjugat: unconjugated
• Antikörperform: IgG fraction of antiserum
• Antikörper-Produkttyp: primary antibodies
• Klon: polyclonal
• Form: buffered aqueous solution
• Mol-Gew.: antigen ~24 kDa (and ~28 kDa)
• Speziesreaktivität: human, rat, mouse
• Methode(n): western blot: 1:250-1:500 using whole extracts of mouse and rat liver and HEK-293T cells expressing human COMT
• UniProt-Hinterlegungsnummer: P21964
• Versandbedingung: dry ice
• Lagertemp.: −20°C
• Posttranslationale Modifikation Target: unmodified
• Angaben zum Gen: human ... COMT(1312) ; mouse ... Comt1(12846) ; rat ... Comt(24267)

Beschreibung

Allgemeine Beschreibung

The gene Catechol-O-methyltransferase (COMT) is mapped to human chromosome 22q11.2. COMT is also referred to as HEL-S-98n. It is widely expressed in various tissues, including brain, liver, kidney, endometrium and breast.

Spezifität

The antibody recognizes MB-COMT and S-COMT.

Anwendung

Anti-COMT (N-terminal) antibody produced in rabbit has been used in immunoblotting.

Biochem./physiol. Wirkung

Catechol-O-methyltransferase (COMT) is a Mg²⁺-dependent enzyme. COMT catalyzes transfer of methyl groups from S-adenosyl methionine to catecholamines. It is responsible for degradation of catecholamines and thereby results in psychiatric disorders and symptoms. Met/Met genotype individuals can acquire skill in executive function tasks (as multi-unmanned vehicles supervisory control, to a higher level and/or faster than other genotype groups). On the other hand, COMT polymorphism is linked to major depressive disorder and bipolar disorder. The genetic variants of COMT alter neurobehavioral functions that are affected by mercury in adults and might modify the adverse neurobehavioral effects of mercury exposure in children. COMT polymorphism is associated with high risk of premature ovarian insufficiency. COMT single nucleotide polymorphism preoperative humans psychological status and postoperative opioid analgesia efficacy. COMT acts as a tumor supressor gene for colorectal cancer cell lines. Overexpression of COMT supresses pancreatic cancer.

Physikalische Form

Solution in 0.01 M phos­phate buffered saline, pH 7.4, containing 15 mM sodium azide.

Haftungsausschluss

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

Sicherheitshinweise

• Lagerklassenschlüssel: 10 - Combustible liquids
• WGK: WGK 2
• Flammpunkt (°F): Not applicable
• Flammpunkt (°C): Not applicable
• Persönliche Schutzausrüstung: Eyeshields, Gloves, multi-purpose combination respirator cartridge (US)