C6499

CTB

≥98% (HPLC)

• Synonym(e): CTPB, N-(4-Chloro-3-trifluoromethyl-phenyl)-2-ethoxy-benzamide
• Empirische Formel (Hill-System): C₁₆H₁₃ClF₃NO₂
• CAS-Nummer: 451491-47-7
• Molekulargewicht: 343.73
• MDL-Nummer: MFCD02356522
• UNSPSC-Code: 12352200
• NACRES: NA.77

Eigenschaften

• Qualitätsniveau: 100
• Assay: ≥98% (HPLC)
• Form: powder
• Farbe: white to off-white
• Löslichkeit: DMSO: >10 mg/mL
• Lagertemp.: 2-8°C
• SMILES String: FC(F)(F)c1c(ccc(c1)NC(=O)c2c(cccc2)OCC)Cl
• InChIKey: YDXZSNHARVUYNM-UHFFFAOYSA-N

Beschreibung

Allgemeine Beschreibung

CTB (N-(4-Chloro-3-trifluoromethyl-phenyl)-2-ethoxy-benzamide) is derived from anacardic acid.

Anwendung

CTB has been used to study its apoptotic effects on P53 protein acetylation.

Biochem./physiol. Wirkung

CBP (CREB binding protein)/p300) histone acetyltransferases (HATs) activator; p300 HAT activator.

CTPB was a first known small molecular activator of histone acetyltransferase p300. CTB is a simplified analog of CTPB with comparable or higher activity. The compound activates the histone acetyltransferase (HAT) activity of p300/EP300/E1A binding protein.

Small molecule activators of HAT such as CTB (N-(4-Chloro-3-trifluoromethyl-phenyl)-2-ethoxy-benzamide) is useful for altering chromatin acetylation directly. It might serve as a therapeutic agent for treating the complications of cognitive dysfunction including neuropsychiatric, neurodevelopmental and neurodegenerative diseases.

Leistungsmerkmale und Vorteile

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Sicherheitshinweise

• Lagerklassenschlüssel: 11 - Combustible Solids
• WGK: WGK 2