C4483
CD152/Fc Chimera, Cytolytic from mouse
recombinant, expressed in NS.1 cells, buffered aqueous solution
Synonym(e):
CTLA4/Fc Chimera, cytolytic
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About This Item
Biologische Quelle
mouse
Qualitätsniveau
Rekombinant
expressed in NS.1 cells
Assay
≥99% (SDS-PAGE)
Form
buffered aqueous solution
Mol-Gew.
97 kDa
Verpackung
pkg of 1 mg
Lagerbedingungen
avoid repeated freeze/thaw cycles
Verunreinigungen
≤1 EU/mg protein Endotoxin level (LAL test)
UniProt-Hinterlegungsnummer
Versandbedingung
wet ice
Lagertemp.
−20°C
Angaben zum Gen
mouse ... Cd152(12477) , Ctla4(12477)
Allgemeine Beschreibung
The complement (C1q) and FcγR I binding sites of the Fcγ2a fragment allow the Fc portion of the fusion protein to effectively facilitate direct antibody directed cytotoxicity (ADCC) and complement directed cytotoxicity (CDC).
Biochem./physiol. Wirkung
CD152 (CTLA4), a cell surface glycoprotein expressed at low levels on activated T cells, is a high affinity receptor for the costimulatory molecules CD80 (B7-1) and CD86 (B7-2). A related cell surface glycoprotein, CD28, binds to CD80 and CD86 with lower affinity. The soluble CD152/Fc chimeric fusion protein blocks the B7/CD28 signaling pathway by binding to CD80 and CD86.
Sonstige Hinweise
The extracellular domain (160 amino acids) of mouse CD152 is fused to mouse IgG2a Fc domain.
Physikalische Form
Solution, 0.2 μm filtered, in phosphate buffered saline, pH 7.4, with no preservative added.
Angaben zur Herstellung
Purified from serum-free tissue culture supernatant
Lagerklassenschlüssel
11 - Combustible Solids
WGK
WGK 3
Flammpunkt (°F)
Not applicable
Flammpunkt (°C)
Not applicable
Persönliche Schutzausrüstung
Eyeshields, Gloves, type N95 (US)
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Amod A Sarnaik et al.
Cancer journal (Sudbury, Mass.), 15(3), 169-173 (2009-06-27)
Metastatic melanoma is a disease associated with poor prognosis, with a median survival reported to range from 6 to 9 months. Patients who are not candidates for surgical resection have an even worse expected survival. This is largely due to
W Steurer et al.
Journal of immunology (Baltimore, Md. : 1950), 155(3), 1165-1174 (1995-08-01)
To test the hypothesis that blockade of B7-triggered costimulation by donor cells could preclude allograft rejection, we coated crude islet allograft preparations in vitro for 1 h with a murine CTLA4/Fc fusion protein. Murine CTLA4/Fc blocks the proliferative response in
Andrew L Mellor et al.
International immunology, 16(10), 1391-1401 (2004-09-08)
Murine dendritic cells (DCs) expressing indoleamine 2,3 dioxygenase (IDO) catabolize tryptophan and can suppress T cell responses elicited in vivo. Here, we identify specific subsets of splenic (CD11c+) dendritic cells competent to mediate IDO-dependent T cell suppression following CTLA4-mediated ligation
Andrew L Mellor et al.
Journal of immunology (Baltimore, Md. : 1950), 171(4), 1652-1655 (2003-08-07)
In mice, immunoregulatory APCs express the dendritic cell (DC) marker CD11c, and one or more distinctive markers (CD8alpha, B220, DX5). In this study, we show that expression of the tryptophan-degrading enzyme indoleamine 2,3 dioxygenase (IDO) is selectively induced in specific
P S Linsley et al.
The Journal of experimental medicine, 174(3), 561-569 (1991-09-01)
Functional interactions between T and B lymphocytes are necessary for optimal activation of an immune response. Recently, the T lymphocyte receptor CD28 was shown to bind the B7 counter-receptor on activated B lymphocytes, and subsequently to costimulate interleukin 2 production
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