B7510

Beauvericin

≥97% (HPLC), suitable for HPLC

• Synonym(e): cyclo(D-α-Hydroxyisovaleryl-L-N-methyl-Phe)₃
• Empirische Formel (Hill-System): C₄₅H₅₇N₃O₉
• CAS-Nummer: 26048-05-5
• Molekulargewicht: 783.95
• MDL-Nummer: MFCD00056846
• UNSPSC-Code: 12352209
• PubChem Substanz-ID: 24891996
• NACRES: NA.26

Eigenschaften

• product name: Beauvericin, ≥97% (HPLC)
• Qualitätsniveau: 200
• Assay: ≥97% (HPLC)
• Form: powder or crystals
• Methode(n): HPLC: suitable
• Farbe: white to off-white
• Lagertemp.: 2-8°C
• SMILES String: CC(C)C1OC(=O)C(Cc2ccccc2)N(C)C(=O)C(OC(=O)C(Cc3ccccc3)N(C)C(=O)C(OC(=O)C(Cc4ccccc4)N(C)C1=O)C(C)C)C(C)C
• InChI: 1S/C45H57N3O9/c1-28(2)37-40(49)46(7)35(26-32-21-15-11-16-22-32)44(53)56-39(30(5)6)42(51)48(9)36(27-33-23-17-12-18-24-33)45(54)57-38(29(3)4)41(50)47(8)34(43(52)55-37)25-31-19-13-10-14-20-31/h10-24,28-30,34-39H,25-27H2,1-9H3
• InChIKey: GYSCAQFHASJXRS-UHFFFAOYSA-N

Beschreibung

Allgemeine Beschreibung

Beauvericin is a cyclohexadepsipeptide from the fungus Beauveria bassiana that belongs to the enniatin antibiotic family. It comprises three D-hydroxyisovaleryl and N-methylphenylalanyl residues each.

Anwendung

Beauvericin has been used as an antimicrobial bioactive compound to test its effect on engineered Saccharomyces cerevisiae strains. It has also been used as a mycotoxin standard in the reverse-phase (RP) high-pressure liquid chromatography (HPLC) to quantify mycotoxins produced by Fusarium oxysporum isolates.

Biochem./physiol. Wirkung

Beauvericin (BEA) is a commercial entomopathogenic mycoinsecticide with antiviral, antibacterial, insecticidal, and cytotoxic properties. It elicits apoptotic and nematicidal activities as well. Beauvericin blocks multidrug efflux and Tor complex 1 (TORC1) kinase. It possesses ionophoric functionality and favors channel formation in patches of ventricular myocytes and synthetic membranes. It is shown to inhibit L-type voltage-dependent Ca²⁺ current in the neuroblastoma cells.

Beauvericin (BEA), a cyclohexadepsipeptide produced by the fungus Beauveria bassiana (Bals.), has antiviral, antibacterial, nematicidal, insecticidal, cytotoxic, and apoptotic activity.

Verpackung

Bottomless glass bottle. Contents are inside inserted fused cone.

Sicherheitshinweise

• Lagerklassenschlüssel: 11 - Combustible Solids
• WGK: WGK 3
• Flammpunkt (°F): Not applicable
• Flammpunkt (°C): Not applicable
• Persönliche Schutzausrüstung: Eyeshields, Gloves, type N95 (US)