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B019

Sigma-Aldrich

Phenoxybenzamin -hydrochlorid

≥97%, powder

Synonym(e):

N-(2-Chlorethyl)-N-(1-methyl-2-phenoxyethyl)-benzylamin -hydrochlorid

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About This Item

Empirische Formel (Hill-System):
C18H22ClNO · HCl
CAS-Nummer:
63-92-3
Molekulargewicht:
340.29
EG-Nummer:
200-569-7
MDL-Nummer:
MFCD00055152
UNSPSC-Code:
12352116
PubChem Substanz-ID:
24277760
NACRES:
NA.77

Qualitätsniveau

100

Assay

≥97%

Form

powder

Farbe

white

Löslichkeit

H2O: slightly soluble
alcohol: soluble
propylene glycol: soluble

Ersteller

Wellspring

Lagertemp.

2-8°C

SMILES String

Cl[H].CC(COc1ccccc1)N(CCCl)Cc2ccccc2

InChI

1S/C18H22ClNO.ClH/c1-16(15-21-18-10-6-3-7-11-18)20(13-12-19)14-17-8-4-2-5-9-17;/h2-11,16H,12-15H2,1H3;1H

InChIKey

VBCPVIWPDJVHAN-UHFFFAOYSA-N

Angaben zum Gen

human ... ADRA1A(148) , ADRA1B(147) , ADRA1D(146) , ADRA2A(150) , ADRA2B(151) , ADRA2C(152)

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Biochem./physiol. Wirkung

Calmodulin antagonist; α-adrenoceptor antagonist.

Leistungsmerkmale und Vorteile

This compound is a featured product for ADME Tox research. Click here to discover more featured ADME Tox products. Learn more about bioactive small molecules for other areas of research at sigma.com/discover-bsm.
This compound was developed by Wellspring. To browse the list of other pharma-developed compounds and Approved Drugs/Drug Candidates, click here.

Piktogramme

Health hazardExclamation mark
GHS08,GHS07

Signalwort

Warning

H-Sätze

H302,H351

Gefahreneinstufungen

Acute Tox. 4 Oral - Carc. 2

Lagerklassenschlüssel

11 - Combustible Solids

WGK

WGK 3

Flammpunkt (°F)

Not applicable

Flammpunkt (°C)

Not applicable

Persönliche Schutzausrüstung

Eyeshields, Gloves, type P3 (EN 143) respirator cartridges

Analysenzertifikate (COA)

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Sigma-Aldrich

P0130

Progesteron

Yu Zhu et al.
Endocrine, 38(2), 254-259 (2010-11-04)
The objective of this article is to evaluate the efficacy of Doxazosin Mesylate Controlled Release Tablets for preoperative treatment of patients with pheochromocytoma. Between 2003 and 2008, 67 patients with confirmed diagnoses of pheochromocytoma were enrolled in this study. According
João Walter S Silveira et al.
Molecular pain, 6, 17-17 (2010-03-25)
Descending pronociceptive pathways may be implicated in states of persistent pain. Paw skin incision is a well-established postoperative pain model that causes behavioral nociceptive responses and enhanced excitability of spinal dorsal horn neurons. The number of spinal c-Fos positive neurons
Brian T Welch et al.
Radiology, 258(1), 301-307 (2010-10-26)
To assess safety, technical success, complications, and hemodynamic changes associated with the adrenal cryoablation procedure. This retrospective review was approved by the institutional review board, with waiver of informed consent, and was compliant with the Health Insurance Portability and Accountability
Is dexmedetomidine the agent of choice in the resection of pheochromocytoma?
Harsha V Polavarapu et al.
The American surgeon, 78(3), E127-E128 (2012-04-25)
Hasan K Siddiqi et al.
Surgery, 152(6), 1027-1036 (2012-11-20)
Calcium channel blockade with nicardipine (NC) is an alternative to phenoxybenzamine (PB) preparation for resection of a pheochromocytoma. Intraoperative magnesium sulfate infusion (+MgSO(4)) is often used for its cardiovascular stabilizing properties. We hypothesized that preparation with NC would be similar
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Verwandter Inhalt

Discover Bioactive Small Molecules for ADME/Tox

Discover Bioactive Small Molecules for ADME/Tox

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