AV32618

Anti-HDAC2 antibody produced in rabbit

affinity isolated antibody

• Synonym(e): Anti-Histone deacetylase 2
• MDL-Nummer: MFCD02096533
• UNSPSC-Code: 12352203
• NACRES: NA.41

Eigenschaften

• Biologische Quelle: rabbit
• Qualitätsniveau: 100
• Konjugat: unconjugated
• Antikörperform: affinity isolated antibody
• Antikörper-Produkttyp: primary antibodies
• Klon: polyclonal
• Form: buffered aqueous solution
• Mol-Gew.: 55 kDa
• Speziesreaktivität: rat, mouse, rabbit, dog, pig, bovine, human
• Konzentration: 0.5 mg - 1 mg/mL
• Methode(n): immunohistochemistry: suitable; western blot: suitable
• NCBI-Hinterlegungsnummer: NP_001518
• UniProt-Hinterlegungsnummer: Q92769
• Versandbedingung: wet ice
• Lagertemp.: −20°C
• Posttranslationale Modifikation Target: unmodified
• Angaben zum Gen: human ... HDAC2(3066)

Beschreibung

Allgemeine Beschreibung

HDAC2 is a member of the deacetylase family that forms transcriptional repressor complexes. Studies have reported that HDAC2 negatively regulates synaptic plasticity, learning and memory functions. In colorectal carcinogenesis, loss of APC is known to induce HDAC2 expression.
Rabbit Anti-HDAC2 recognizes bovine, human, canine, chicken, rat, and mouse HDAC2.

Immunogen

Synthetic peptide directed towards the C terminal region of human HDAC2

Anwendung

Rabbit Anti-HDAC2 antibody can be used for western blot (0.2-2.0μg/ml) and IHC (4-8μg/ml) applications.

Biochem./physiol. Wirkung

Histone deacetylase 2 (HDAC2), or transcriptional regulator homolog RPD3 L1, is highly homologous to the yeast transcription factor RPD3 (reduced potassium dependency 3) gene. As in yeast, human HDA2 is likely to be involved in regulating chromatin structure during transcription. It has been implicated to associate with YY1, a mammalian zinc-finger transcription factor, which negatively regulates transcription by tethering RPD3 to DNA as a cofactor. This process is highly concerved from yeast to human.

Sequenz

Synthetic peptide located within the following region: EEFSDSEDEGEGGRRNVADHKKGAKKARIEEDKKETEDKKTDVKEEDKSK

Physikalische Form

Purified antibody supplied in 1x PBS buffer with 0.09% (w/v) sodium azide and 2% sucrose.

Haftungsausschluss

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

Sicherheitshinweise

• Lagerklassenschlüssel: 10 - Combustible liquids
• WGK: WGK 3
• Flammpunkt (°F): Not applicable
• Flammpunkt (°C): Not applicable