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A9834

Sigma-Aldrich

2-Amino-5,6-dihydro-6-methyl-4H-1,3-thiazine

≥98%

Synonym(e):

AMT

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About This Item

Empirische Formel (Hill-System):
C5H10N2S · HCl
CAS-Nummer:
1121-91-1
Molekulargewicht:
166.67
MDL-Nummer:
MFCD00717539
UNSPSC-Code:
12352202
PubChem Substanz-ID:
24278017
NACRES:
NA.77

Biologische Quelle

synthetic (organic)

Qualitätsniveau

200

Assay

≥98%

Form

powder

Löslichkeit

water: 25 mg/mL, clear, colorless

Lagertemp.

2-8°C

SMILES String

Cl[H].CC1CCN=C(N)S1

InChI

1S/C5H10N2S.ClH/c1-4-2-3-7-5(6)8-4;/h4H,2-3H2,1H3,(H2,6,7);1H

InChIKey

HVJCRMIQAMEJNM-UHFFFAOYSA-N

Angaben zum Gen

human ... FPGS(2356)

Biochem./physiol. Wirkung

As a selective type II (inducible) nitric oxide synthase (NOS) inhibitor, AMT was tested against LPS-induced inflammation in rats.

Lagerklassenschlüssel

11 - Combustible Solids

WGK

WGK 3

Flammpunkt (°F)

Not applicable

Flammpunkt (°C)

Not applicable

Persönliche Schutzausrüstung

dust mask type N95 (US), Eyeshields, Gloves

Analysenzertifikate (COA)

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W R Tracey et al.
Canadian journal of physiology and pharmacology, 73(5), 665-669 (1995-05-01)
Selective type II (inducible) nitric oxide synthase (NOS) inhibitors have several potential therapeutic applications, including treatment of sepsis, diabetes, and autoimmune diseases. The ability of two novel, selective inhibitors of type II NOS, S-ethylisothiourea (EIT) and 2-amino-5,6-dihydro-6-methyl-4H-1,3-thiazine (AMT), to inhibit
M Nakane et al.
Molecular pharmacology, 47(4), 831-834 (1995-04-01)
We have identified two novel potent and selective inhibitors of inducible nitric oxide synthase, S-ethylisothiourea and 2-amino-5,6-dihydro-6-methyl-4H-1,3-thiazine. Ki values of 14.7 nM for S-ethylisothiourea and 4.2 nM for 2-amino-5,6-dihydro-6-methyl-4H-1,3-thiazine were obtained with partially purified preparations of inducible nitric oxide synthase.
Axelle Cooreman et al.
International journal of molecular sciences, 23(9) (2022-05-15)
Connexin43 (Cx43) hemichannels form a pathway for cellular communication between the cell and its extracellular environment. Under pathological conditions, Cx43 hemichannels release adenosine triphosphate (ATP), which triggers inflammation. Over the past two years, azithromycin, chloroquine, dexamethasone, favipiravir, hydroxychloroquine, lopinavir, remdesivir
Ju Hee Lee et al.
Archives of pharmacal research, 38(7), 1304-1311 (2015-03-07)
The aerial parts of Houttuynia cordata used for treating inflammation-related disorders contain flavonoids as major constituents. Since certain flavonoids possess anti-inflammatory activity, especially in the lung, the pharmacological activities of H. cordata and the flavonoid constituents were evaluated using in

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