A9227

ABT-491 hydrochloride

≥98% (HPLC)

• Synonym(e): 4-Ethynyl-N,N-dimethyl-3-[3-fluoro-4-[(2-methyl-1H-imidazo-[4,5-c]pyridin-1-yl)methyl]benzoyl]-1H-indole-1-carboxamide hydrochloride, A-137491
• Empirische Formel (Hill-System): C₂₈H₂₂N₅O₂F · HCl
• CAS-Nummer: 189689-94-9
• Molekulargewicht: 515.97
• MDL-Nummer: MFCD00945301
• UNSPSC-Code: 12352200
• PubChem Substanz-ID: 24724404
• NACRES: NA.77

Eigenschaften

• Qualitätsniveau: 100
• Assay: ≥98% (HPLC)
• Form: solid
• Lagerbedingungen: desiccated
• Farbe: white to beige
• mp (Schmelzpunkt): 170-178 °C (lit.)
• Löslichkeit: H₂O: freely soluble 22 mg/mL
• Ersteller: Abbott
• Lagertemp.: 2-8°C
• SMILES String: Cl[H].CN(C)C(=O)n1cc(C(=O)c2ccc(Cn3c(C)nc4cnccc34)c(F)c2)c5c(cccc15)C#C
• InChI: 1S/C28H22FN5O2.ClH/c1-5-18-7-6-8-25-26(18)21(16-34(25)28(36)32(3)4)27(35)19-9-10-20(22(29)13-19)15-33-17(2)31-23-14-30-12-11-24(23)33;/h1,6-14,16H,15H2,2-4H3;1H
• InChIKey: AWRGBOKANQBIBM-UHFFFAOYSA-N

Beschreibung

Biochem./physiol. Wirkung

Highly potent, selective and orally active platelet-activating factor (PAF) receptor antagonist. K_i = 0.6 nM in human platelets.

Leistungsmerkmale und Vorteile

This compound is featured on the PAF Receptor page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.

This compound was developed by Abbott. To browse the list of other pharma-developed compounds and Approved Drugs/Drug Candidates, click here.

Sicherheitshinweise

• Lagerklassenschlüssel: 11 - Combustible Solids
• WGK: WGK 3
• Flammpunkt (°F): Not applicable
• Flammpunkt (°C): Not applicable
• Persönliche Schutzausrüstung: Eyeshields, Gloves, type N95 (US)