A6011

Acetazolamid

≥99%, powder

• Synonym(e): 5-Acetamido-1,3,4-thiadiazol-2-sulfonamid, N-(5-Sulfamoyl-1,3,4-thiadiazol-2-yl)-acetamid, N-[5-(Aminosulfonyl)-1,3,4-thiadiazol-2-yl)-acetamid
• Empirische Formel (Hill-System): C₄H₆N₄O₃S₂
• CAS-Nummer: 59-66-5
• Molekulargewicht: 222.25
• EG-Nummer: 200-440-5
• MDL-Nummer: MFCD00003105
• UNSPSC-Code: 12352202
• PubChem Substanz-ID: 57653866
• NACRES: NA.77

Eigenschaften

• Biologische Quelle: synthetic
• Qualitätsniveau: 200
• Assay: ≥99%
• Form: powder
• pKa: 7.2
• mp (Schmelzpunkt): 258-259 °C
• Löslichkeit: 1 M NH4OH: 50 mg/mL; DMSO: soluble; methanol and ethanol: slightly soluble
• SMILES String: CC(=O)Nc1nnc(s1)S(N)(=O)=O
• InChI: 1S/C4H6N4O3S2/c1-2(9)6-3-7-8-4(12-3)13(5,10)11/h1H3,(H2,5,10,11)(H,6,7,9)
• InChIKey: BZKPWHYZMXOIDC-UHFFFAOYSA-N
• Angaben zum Gen: human ... CA1(759) , CA12(771) , CA14(23632) , CA2(760) , CA3(761) , CA4(762) , CA5A(763) , CA5B(11238) , CA9(768) ; mouse ... Car13(71934) , Car5a(12352) ; rat ... Car2(54231) , Car4(29242)

Beschreibung

Anwendung

Acetazolamide has been used:

• to study its protective effect on steatotic liver grafts against cold ischemia reperfusion injury{49)
• to determine its ability to bind isolated porcine retinal pigment epithelium (RPE) melanin by cassette dosing and rapid equilibrium dialysis inserts
• to validate the in vitro gastrulation model of P19C5 stem cells for developmental toxicity screening assays
• to study its inhibitory effect on melanogenesis through enzyme kinetic, in vitro, in vivo and in silico analyses in zebrafish and in A375 human melanoma cells

Carboanhydrasehemmer; erhöht den zerebralen Blutfluss.

Biochem./physiol. Wirkung

Hemmt die Wasserdurchlässigkeit von Membranen durch Interaktion mit Aquaporinen

Acetazolamide is a member of sulfonamide drug family. It as an ability to inhibit the activity of carbonic anhydrase. It rapidly increases cerebral blood flow (CBF) and is used as an investigative tool in CBF studies. Acetazolamide acts as a therapeutic agent for epilepsy, glaucoma and pseudotumor cerebri.

Sicherheitshinweise

• Piktogramme: GHS07
• Signalwort: Warning
• H-Sätze: H315,H319
• P-Sätze: P264 - P280 - P302 + P352 - P305 + P351 + P338 - P332 + P313 - P337 + P313
• Gefahreneinstufungen: Eye Irrit. 2 - Skin Irrit. 2
• Lagerklassenschlüssel: 11 - Combustible Solids
• WGK: WGK 3
• Flammpunkt (°F): Not applicable
• Flammpunkt (°C): Not applicable
• Persönliche Schutzausrüstung: dust mask type N95 (US), Eyeshields, Gloves