A5080

Amyloid β-Protein Fragment 22-35

≥95% (HPLC)

• Empirische Formel (Hill-System): C₅₉H₁₀₂N₁₆O₂₁S
• CAS-Nummer: 144189-71-9
• Molekulargewicht: 1403.60
• MDL-Nummer: MFCD00236784
• UNSPSC-Code: 12352202
• PubChem Substanz-ID: 24890940
• NACRES: NA.32

Eigenschaften

• Qualitätsniveau: 200
• Assay: ≥95% (HPLC)
• Form: powder
• UniProt-Hinterlegungsnummer: P05067
• Lagertemp.: −20°C
• SMILES String: CCC(C)C(NC(=O)C(NC(=O)C(C)NC(=O)CNC(=O)C(CCCCN)NC(=O)C(CC(N)=O)NC(=O)C(CO)NC(=O)CNC(=O)C(NC(=O)C(CC(O)=O)NC(=O)C(N)CCC(O)=O)C(C)C)C(C)CC)C(=O)NCC(=O)NC(CC(C)C)C(=O)NC(CCSC)C(O)=O
• InChI: 1S/C59H102N16O21S/c1-11-30(7)47(57(93)65-25-42(79)67-36(21-28(3)4)52(88)70-35(59(95)96)18-20-97-10)75-58(94)48(31(8)12-2)74-49(85)32(9)66-41(78)24-63-51(87)34(15-13-14-19-60)69-53(89)37(22-40(62)77)72-55(91)39(27-76)68-43(80)26-64-56(92)46(29(5)6)73-54(90)38(23-45(83)84)71-50(86)33(61)16-17-44(81)82/h28-39,46-48,76H,11-27,60-61H2,1-10H3,(H2,62,77)(H,63,87)(H,64,92)(H,65,93)(H,66,78)(H,67,79)(H,68,80)(H,69,89)(H,70,88)(H,71,86)(H,72,91)(H,73,90)(H,74,85)(H,75,94)(H,81,82)(H,83,84)(H,95,96)
• InChIKey: KUDAPIFTNDCCFG-UHFFFAOYSA-N
• Angaben zum Gen: human ... APP(351)

Beschreibung

Amino Acid Sequence

Glu-Asp-Val-Gly-Ser-Asn-Lys-Gly-Ala-Ile-Ile-Gly-Leu-Met

Biochem./physiol. Wirkung

Has cytotoxic effect on cultured neurons from rat hippocampus in serum free medium. Also forms aggregates and fibrils similar to those of β-amyloid protein in senile plaque cores.

Sicherheitshinweise

• Lagerklassenschlüssel: 11 - Combustible Solids
• WGK: WGK 3
• Flammpunkt (°F): Not applicable
• Flammpunkt (°C): Not applicable
• Persönliche Schutzausrüstung: Eyeshields, Gloves, type N95 (US)