A0384

Arcaine sulfate salt

• Synonym(e): 1,4-Diguanidinobutane sulfate salt
• Empirische Formel (Hill-System): C₆H₁₆N₆ · H₂O₄S
• CAS-Nummer: 14923-17-2
• Molekulargewicht: 270.31
• MDL-Nummer: MFCD00050545
• UNSPSC-Code: 12352200
• PubChem Substanz-ID: 24277954
• NACRES: NA.77

Eigenschaften

• Biologische Quelle: synthetic (organic)
• Assay: ≥98% (TLC)
• Form: powder
• mp (Schmelzpunkt): >280 °C
• Löslichkeit: 1 M NaOH: 50 mg/mL, clear to slightly hazy, colorless to faintly yellow
• SMILES String: OS(O)(=O)=O.NC(=N)NCCCCNC(N)=N
• InChI: 1S/C6H16N6.H2O4S/c7-5(8)11-3-1-2-4-12-6(9)10;1-5(2,3)4/h1-4H2,(H4,7,8,11)(H4,9,10,12);(H2,1,2,3,4)
• InChIKey: RWTGFMPOODRXIM-UHFFFAOYSA-N
• Angaben zum Gen: human ... GRIN1(2902) , GRIN2A(2903) , GRIN2B(2904) , GRIN2C(2905) , GRIN2D(2906) , GRINA(2907)

Beschreibung

Anwendung

Arcaine sulfate salt has been used as an N-methyl-d-aspartate (NMDA) receptor effector/antagonist:

• to evaluate its effects on the acquisition of electrical kindling of the amygdala
• to compare its effects with agmatine and MK801 on NMDA- or glutamate-induced neuronal damage
• to study its effects on cell-free translation of synthetic polynucleotide

Biochem./physiol. Wirkung

Arcaine sulfate salt (1,4-diguanidinobutane), a polyamine, is an antagonist of the polyamine binding site of the N-methyl-d-aspartate (NMDA) receptor. Arcaine, an agmatine analog, along with ifenprodil, might have a possibility for therapeutic management in epileptic disorders.

Sicherheitshinweise

• Lagerklassenschlüssel: 11 - Combustible Solids
• WGK: WGK 3
• Flammpunkt (°F): Not applicable
• Flammpunkt (°C): Not applicable
• Persönliche Schutzausrüstung: Eyeshields, Gloves, type N95 (US)