487R-9

SMAD4 (MRQ-72) Rabbit Monoclonal Antibody

• Synonym(e): Mothers Against Decapentaplegic Homolog 4 Rabbit Monoclonal Antibody
• UNSPSC-Code: 12352203

Eigenschaften

• Biologische Quelle: rabbit
• Qualitätsniveau: 500
• Antikörper-Produkttyp: primary antibodies
• Klon: MRQ-72, monoclonal
• Beschreibung: For In Vitro Diagnostic Use in Select Regions
• Verpackung: vial of 0.1 mL concentrate (487R-94); vial of 0.1 mL concentrate (487R-94-RUO) Research Use Only; vial of 0.5 mL concentrate (487R-(95); vial of 1.0 mL (concentrate (487R-96)); vial of 1.0 mL concentrate (487R-96-RUO) Research Use Only; vial of 1.0 mL pre-dilute (487R-97-RUO) Research Use Only; vial of 1.0 mL pre-dilute ready-to-use (487R-97); vial of 7.0 mL pre-dilute ready-to-use (487R-98); vial of 7.0 mL pre-dilute ready-to-use (487R-98-RUO) Research Use Only
• Hersteller/Markenname: Cell Marque^™
• Isotyp: IgG
• Kontrolle: pancreas
• Visualisierung: cytoplasmic, nuclear

Beschreibung

Allgemeine Beschreibung

Mothers Against Decapentaplegic Homolog 4 (SMAD4) is a transcription factor that is involved in TGFβ signalling pathways and acts as a tumor suppressor. SMAD4 is commonly expressed in a variety of cancers, including pancreatic ductal adenocarcinoma (PDA), colorectal carcinoma (CRC), hepatocellular carcinoma (HCC), and gastric carcinomas, as well as non-neoplastic liver, pancreas, and colon. However, a loss of expression has been observed in a subset of PDA, CRC, and gastric carcinomas due to a variety of mutations including nonsense, missense, deletions, and splice site changes. In contrast, SMAD4 is over-expressed in HCC compared to the weak expression that is exhibited in the non-neoplastic liver.

Qualität

IVD - MQ500

RUO - MQ100

Physikalische Form

Solution in Tris Buffer, pH 7.3-7.7, with 1% BSA and <0.1% Sodium Azide.

Angaben zur Herstellung

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Sonstige Hinweise

For Technical Service please contact: 800-665-7284 or email: service@cellmarque.com

Rechtliche Hinweise

Cell Marque is a trademark of Merck KGaA, Darmstadt, Germany

Sicherheitshinweise

• Lagerklassenschlüssel: 12 - Non Combustible Liquids
• WGK: WGK 2