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Merck

451M-1

Sigma-Aldrich

h-Caldesmon (hHCD) Mouse Monoclonal Antibody

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About This Item

UNSPSC-Code:
12352203

Biologische Quelle

mouse

Qualitätsniveau

100
500

Konjugat

unconjugated

Antikörperform

diluted ascites fluid

Antikörper-Produkttyp

primary antibodies

Klon

hHCD, monoclonal

Beschreibung

For In Vitro Diagnostic Use in Select Regions

Form

buffered aqueous solution

Speziesreaktivität

human

Verpackung

vial of 0.1 mL concentrate (451M-14)
vial of 0.1 mL concentrate Research Use Only (451M-14-RUO)
vial of 0.5 mL concentrate (451M-15)
vial of 1.0 mL concentrate (451M-16)
vial of 1.0 mL concentrate Research Use Only (451M-16-RUO)
vial of 1.0 mL pre-dilute Research Use Only (451M-17-RUO)
vial of 1.0 mL pre-dilute ready-to-use (451M-17)
vial of 7.0 mL pre-dilute ready-to-use (451M-18)
vial of 7.0 mL pre-dilute ready-to-use Research Use Only (451M-18-RUO)

Hersteller/Markenname

Cell Marque

Methode(n)

immunohistochemistry (formalin-fixed, paraffin-embedded sections): 1:50-1:100 (concentrated)

Isotyp

IgG1

Kontrolle

bladder, colon, leiomyoma, smooth muscle tumors, stomach

Versandbedingung

wet ice

Lagertemp.

2-8°C

Visualisierung

cytoplasmic

Allgemeine Beschreibung

Caldesmon is a protein that facilitates the regulation of cellular contraction through complexing with calmodulin, tropomyosin, and actin. Its high molecular weight isoform (h-caldesmon) has been identified to have restricted expression in visceral and vascular smooth muscle cells. In particular, strong expression of h-caldesmon has been observed in non-neoplastic uterine myometrium while being entirely absent in the endometrial layer. In spindle cell tumor pathology, overlapping immunohistochemical staining profiles between smooth muscle cells and myofibroblastic cells has not allowed for reliable identification of true smooth muscle tumors. Immunohistochemical detection of h-caldesmon has been demonstrated to aid in the distinguishing smooth muscle tumors, such as leiomyoma and leiomyosarcoma from myofibroblastic lesions, such as inflammatory myofibroblastic tumors and fibromatoses.

Qualität


IVD

IVD

IVD

RUO

Physikalische Form

Solution in Tris Buffer, pH 7.3-7.7, with 1% BSA and <0.1% Sodium Azide.

Angaben zur Herstellung

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Sonstige Hinweise

For Technical Service please contact: 800-665-7284 or email: service@cellmarque.com

Rechtliche Hinweise

Cell Marque is a trademark of Merck KGaA, Darmstadt, Germany

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Lagerklassenschlüssel

12 - Non Combustible Liquids

WGK

WGK 2


Analysenzertifikate (COA)

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In der Dokumentenbibliothek finden Sie die Dokumentation zu den Produkten, die Sie kürzlich erworben haben.

Die Dokumentenbibliothek aufrufen

K M Ceballos et al.
American journal of clinical pathology, 114(5), 746-753 (2000-11-09)
Misinterpretation of positive staining of antibodies to desmin, smooth muscle actin, and muscle actin as representing smooth muscle differentiation in the context of a spindle cell tumor is not uncommon. Anti-h-caldesmon is a promising novel immunohistochemical reagent for more specific
M R Nucci et al.
The American journal of surgical pathology, 25(4), 455-463 (2001-03-21)
Distinction of endometrial stromal neoplasms from cellular smooth muscle tumors of the uterus is sometimes difficult. Immunohistochemistry is often not helpful because muscle actins and desmin are expressed in both neoplasms. This study's goal was to determine whether h-caldesmon, a

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