SYNPLE-P072

Reagent-cartridge CRBN-COOH-PEG2

Synple

• Synonym(e): Synple 2
• MDL-Nummer: MFCD32903606
• UNSPSC-Code: 12352401
• NACRES: NA.22

Eigenschaften

• SMILES String: [s]1cnc(c1c2ccc(cc2)CNC(=O)[C@H]3N(C[C@@H](C3)O)C(=O)[C@@H](NC(=O)CCOCCC(=O)O)C(C)(C)C)C
• InChI: 1S/C28H38N4O7S/c1-17-24(40-16-30-17)19-7-5-18(6-8-19)14-29-26(37)21-13-20(33)15-32(21)27(38)25(28(2,3)4)31-22(34)9-11-39-12-10-23(35)36/h5-8,16,20-21,25,33H,9-15H2,1-4H3,(H,29,37)(H,31,34)(H,35,36)/t20-,21+,25-/m1/s1
• InChIKey: HVPZHRHEHKZOOJ-TYBLODHISA-N

Beschreibung

Allgemeine Beschreibung

Reagent-cartridge CRBN-COOH-PEG2 is a reagent cartridge for the Synple 2 Automated Synthesizer that enables the synthesis of molecules for targeted protein degradation and PROTAC^® (proteolysis-targeting chimeras) research. The cartridge contains all necessary reagents for linking the user selected amine to the carboxylic acid terminated linker through an amide coupling. This cartridge features a Cereblon (CRBN) recruiting ligand (pomalidomide) and PEG linker. Because even slight alterations in ligands and crosslinkers can affect ternary complex formation between the target, E3 ligase, and degrader, many analogs are prepared to screen for optimal target degradation.

Scale: up to 0.1 mmol


Linker: PEG2


E3 ligase target and ligand: Cereblon (CRBN), pomalidomide


Terminal functional group: carboxylic acid


Compatible substrates: amine
Cartridge contents:

• Supported carbodiimide and Oxyma Pure (coupling reagents)
• Supported carbonate (acid scavenger)
• SCX2 (for purification)
• Degrader building block linker reagent

Related Cartridges:

• SYNPLE-P002 Reagent-cartridge CRBN-PEG2
  
• SYNPLE-P003 Reagent-cartridge CRBN-PEG3
• SYNPLE-P004 Reagent-cartridge CRBN-PEG4
• SYNPLE-P005 Reagent-cartridge CRBN-PEG5
• SYNPLE-P021 Reagent-cartridge VHL-PEG1
• SYNPLE-P022 Reagent-cartridge VHL-PEG2
• SYNPLE-P023 Reagent-cartridge VHL-PEG3
• SYNPLE-P024 Reagent-cartridge VHL-PEG4
• SYNPLE-P025 Reagent-cartridge VHL-PEG5
• SYNPLE-P073 Reagent-cartridge CRBN-COOH-PEG3
• SYNPLE-P074 Reagent-cartridge CRBN-COOH-PEG4
• SYNPLE-P082 Reagent-cartridge VHL-COOH-PEG2
• SYNPLE-P083 Reagent-cartridge VHL-COOH-PEG3
• SYNPLE-P084 Reagent-cartridge VHL-COOH-PEG4

Learn more about the Synple automated synthesis platform.

Learn more about protein degradation.

Explore all our Protein Degrader Building Blocks.

Features and Benefits of Synple Platform

• Time savings – pre-installed protocols have been highly optimized, which obviates the need for the user’s own reaction development and optimization
• Easy to use – protocols are loaded by simply scanning the cartridge; does not requires any programming knowledge
• Safety – all chemicals are contained in the system, minimizing the user’s exposure
• Set-up reaction in less than 5 minutes
• Small footprint
• Plug & Play system – simple installation
• Reaction temperatures from 25 °C – 80 °C
• Cartridges available for many different reactions
• Prefilled with all required reagents
• RFID chip containing optimized reaction protocol

Sonstige Hinweise

References
An integrated console for capsule-based, automatedorganic synthesis

Rechtliche Hinweise

Product of Synple Chem AG

PROTAC is a registered trademark of Arvinas Operations, Inc., and is used under license

Sicherheitshinweise

• Lagerklassenschlüssel: 13 - Non Combustible Solids
• WGK: WGK 3
• Flammpunkt (°F): Not applicable
• Flammpunkt (°C): Not applicable