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Merck

PHR1797

Supelco

Imipramin-Hydrochlorid

Pharmaceutical Secondary Standard; Certified Reference Material

Synonym(e):

Imipramin -hydrochlorid, 10,11-Dihydro-N,N-dimethyl-5H-dibenz[b,f]azepin-5-propanamin -hydrochlorid, 5-[3-(Dimethylamino)-propyl]-10,11-dihydro-5H-dibenz[b,f]azepin -hydrochlorid

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About This Item

Empirische Formel (Hill-System):
C19H24N2 · HCl
CAS-Nummer:
Molekulargewicht:
316.87
EG-Nummer:
MDL-Nummer:
UNSPSC-Code:
41116107
PubChem Substanz-ID:
NACRES:
NA.24

Qualität

certified reference material
pharmaceutical secondary standard

Qualitätsniveau

Agentur

traceable to BP 932
traceable to Ph. Eur. I0100000
traceable to USP 1338007

API-Familie

imipramine

Analysenzertifikat (CofA)

current certificate can be downloaded

Verpackung

pkg of 1 g

Methode(n)

HPLC: suitable
gas chromatography (GC): suitable

Anwendung(en)

pharmaceutical (small molecule)

Format

neat

Lagertemp.

2-30°C

SMILES String

Cl[H].CN(C)CCCN1c2ccccc2CCc3ccccc13

InChI

1S/C19H24N2.ClH/c1-20(2)14-7-15-21-18-10-5-3-8-16(18)12-13-17-9-4-6-11-19(17)21;/h3-6,8-11H,7,12-15H2,1-2H3;1H

InChIKey

XZZXIYZZBJDEEP-UHFFFAOYSA-N

Angaben zum Gen

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Allgemeine Beschreibung

Pharmaceutical secondary standards for application in quality control, provide pharma laboratories and manufacturers with a convenient and cost-effective alternative to the preparation of in-house working standards.
Imipramine Hydrochloride is typically utilized for the treatment of depressive disorders due to its efficiency in uplifting the patients′ mood by interfering in the reuptake of norepinephrine or serotonin.

Anwendung

Imipramine Hydrochloride may be used as a pharmaceutical reference standard for the determination of the analyte in pharmaceutical formulations by chromatography and spectrophotometry techniques.
These Secondary Standards are qualified as Certified Reference Materials. These are suitable for use in several analytical applications including but not limited to pharma release testing, pharma method development for qualitative and quantitative analyses, food and beverage quality control testing, and other calibration requirements.

Biochem./physiol. Wirkung

Tricyclisches Antidepressivum; hemmt die Serotonin- und Noradrenalin-Transporter mit Kis von 7.7 nM bzw. 67 nM. Hat wenig Einfluss auf Dopamin-Transporter (Ki = 25 μM).
Tricyclisches Antidepressivum; hemmt die Serotonin- und Noradrenalin-Transporter, hat wenig Einfluss auf Dopamin-Transporter.

Hinweis zur Analyse

These secondary standards offer multi-traceability to the USP, EP and BP primary standards, where they are available.

Sonstige Hinweise

This Certified Reference Material (CRM) is produced and certified in accordance with ISO 17034 and ISO/IEC 17025. All information regarding the use of this CRM can be found on the certificate of analysis.

Fußnote

To see an example of a Certificate of Analysis for this material enter LRAA8623 in the Documents slot below. This is an example certificate only and may not be the lot that you receive.

Piktogramme

Skull and crossbones

Signalwort

Danger

H-Sätze

Gefahreneinstufungen

Acute Tox. 2 Oral

Lagerklassenschlüssel

6.1A - Combustible acute toxic Cat. 1 and 2 / very toxic hazardous materials

WGK

WGK 1

Flammpunkt (°F)

Not applicable

Flammpunkt (°C)

Not applicable


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Analysenzertifikate (COA)

Lot/Batch Number

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Second-order derivative spectrophotometric assay for imipramine hydrochloride and diazepam in pure admixtures and in dosage forms.
Umapathi P and Parimoo P
Journal of Pharmaceutical and Biomedical Analysis, 13(8), 1003-1009 (1995)
Application of two chemometric methods for the determination of imipramine, amitriptyline and perphenazine in content uniformity and drug dissolution studies.
Markopoulou CK, et al.
Journal of Pharmaceutical and Biomedical Analysis, 37(2), 249-258 (2005)
Simultaneous determination of imipramine hydrochloride and chlordiazepoxide in pharmaceutical preparations by spectrophotometric, RP-HPLC, and HPTLC methods.
Patel SK and Patel NJ
Journal of AOAC (Association of Official Analytical Chemists) International, 93(3), 904-910 (2010)
Simultaneous spectrophotometric estimation of imipramine hydrochloride and chlordiazepoxide in tablets.
Patel S, et al.
Indian Journal of Pharmaceutical Sciences, 71(4), 468-468 (2009)

Artikel

Analysis of 20 pharmaceutical compounds in calf serum using Supel™ Swift HLB SPE cartridge for cleanup and LC-MS determination and another commercially available HLB cartridge for comparison.

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