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Merck

PHR1549

Supelco

1,4-Dioxan

Pharmaceutical Secondary Standard; Certified Reference Material

Synonym(e):

Diethylenoxid, Dioxan

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About This Item

Empirische Formel (Hill-System):
C4H8O2
CAS-Nummer:
Molekulargewicht:
88.11
Beilstein:
102551
EG-Nummer:
MDL-Nummer:
UNSPSC-Code:
41116107
PubChem Substanz-ID:
NACRES:
NA.24

Qualität

certified reference material
pharmaceutical secondary standard

Qualitätsniveau

Agentur

traceable to USP 1601521

Dampfdichte

3 (vs air)

Dampfdruck

27 mmHg ( 20 °C)
40 mmHg ( 25 °C)

Analysenzertifikat (CofA)

current certificate can be downloaded

Selbstzündungstemp.

356 °F

Expl.-Gr.

22 %

Verpackung

ampule of 3x1.2 mL each

Methode(n)

HPLC: suitable
gas chromatography (GC): suitable

Brechungsindex

n20/D 1.422 (lit.)

bp

100-102 °C (lit.)

mp (Schmelzpunkt)

10-12 °C (lit.)

Dichte

1.034 g/mL at 25 °C (lit.)

Anwendung(en)

pharmaceutical (small molecule)

Format

neat

Lagertemp.

2-30°C

SMILES String

C1COCCO1

InChI

1S/C4H8O2/c1-2-6-4-3-5-1/h1-4H2

InChIKey

RYHBNJHYFVUHQT-UHFFFAOYSA-N

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Allgemeine Beschreibung

1,4-Dioxane belongs to the class of volatile organic compounds (VOCs).
Pharmaceutical secondary standards for application in quality control, provide pharma laboratories and manufacturers with a convenient and cost-effective alternative to the preparation of in-house working standards.

Anwendung

1,4-Dioxane may be used as a pharmaceutical reference standard for the determination of the analyte in bulk pharmaceuticals, and cosmetic raw materials and finished products by chromatography.
These Secondary Standards are qualified as Certified Reference Materials. These are suitable for use in several analytical applications including but not limited to pharma release testing, pharma method development for qualitative and quantitative analyses, food and beverage quality control testing, and other calibration requirements.

Hinweis zur Analyse

These secondary standards offer multi-traceability to the USP, EP and BP primary standards, where they are available.

Sonstige Hinweise

This Certified Reference Material (CRM) is produced and certified in accordance with ISO 17034 and ISO/IEC 17025. All information regarding the use of this CRM can be found on the certificate of analysis.

Fußnote

To see an example of a Certificate of Analysis for this material enter LRAC0289 in the slot below. This is an example certificate only and may not be the lot that you receive.

Empfohlene Produkte

Find a digital Reference Material for this product available on our online platform ChemisTwin® for NMR. You can use this digital equivalent on ChemisTwin® for your sample identity confirmation and compound quantification (with digital external standard). An NMR spectrum of this substance can be viewed and an online comparison against your sample can be performed with a few mouseclicks. Learn more here and start your free trial.

Signalwort

Danger

Gefahreneinstufungen

Carc. 1B - Eye Irrit. 2 - Flam. Liq. 2 - STOT SE 3

Zielorgane

Respiratory system

Zusätzliche Gefahrenhinweise

Lagerklassenschlüssel

3 - Flammable liquids

WGK

WGK 3

Flammpunkt (°F)

51.8 °F - closed cup

Flammpunkt (°C)

11 °C - closed cup


Hier finden Sie alle aktuellen Versionen:

Analysenzertifikate (COA)

Lot/Batch Number

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Kunden haben sich ebenfalls angesehen

Occurrence of 1, 4-dioxane in cosmetic raw materials and finished cosmetic products
Black RE, et al.
Journal of AOAC (Association of Official Analytical Chemists) International, 84(3), 666-670 (2001)
A capillary gas chromatographic procedure for the analysis of nine common residual solvents in water-insoluble bulk pharmaceuticals
Li QC, et al.
Journal of Chromatographic Science, 36(3), 119-124 (1998)
Establishment of a knowledge base for prescreening residual solvents in pharmaceuticals
Qin L, et al.
Chromatographia, 59(7-8), 475-480 (2004)
Simultaneous determination of 22 volatile organic compounds, methyl-tert-butyl ether, 1, 4-dioxane, 2-methylisoborneol and geosmin in water by headspace solid phase microextraction-gas chromatography-mass spectrometry
Nakamura S and Daishima S
Analytica Chimica Acta, 548(1-2), 79-85 (2005)
Joshua J Pacheco et al.
Proceedings of the National Academy of Sciences of the United States of America, 111(23), 8363-8367 (2014-06-10)
Terephthalic acid (PTA), a monomer in the synthesis of polyethylene terephthalate (PET), is obtained by the oxidation of petroleum-derived p-xylene. There is significant interest in the synthesis of renewable, biomass-derived PTA. Here, routes to PTA starting from oxidized products of

Protokolle

US EPA Method 8270 (Appendix IX): GC Analysis of Semivolatiles on Equity®-5 (30 m x 0.25 mm I.D., 0.50 μm)

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