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P0597

Sigma-Aldrich

Pilocarpin -nitrat

meets USP testing specifications

Synonym(e):

Pilocarpin -nitrat (Salz)

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About This Item

Empirische Formel (Hill-System):
C11H16N2O2 · HNO3
CAS-Nummer:
148-72-1
Molekulargewicht:
271.27
Beilstein:
4171406
EG-Nummer:
205-723-7
MDL-Nummer:
MFCD00078497
UNSPSC-Code:
12352200
PubChem Substanz-ID:
24898116
NACRES:
NA.21

Agentur

USP/NF
meets USP testing specifications

Qualitätsniveau

200

Form

crystals

Anwendung(en)

pharmaceutical (small molecule)

SMILES String

O[N+]([O-])=O.CC[C@H]1[C@H](COC1=O)Cc2cncn2C

InChI

1S/C11H16N2O2.HNO3/c1-3-10-8(6-15-11(10)14)4-9-5-12-7-13(9)2;2-1(3)4/h5,7-8,10H,3-4,6H2,1-2H3;(H,2,3,4)/t8-,10-;/m0./s1

InChIKey

PRZXEPJJHQYOGF-GNAZCLTHSA-N

Angaben zum Gen

human ... CHRM1(1128) , CHRM3(1131)

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Biochem./physiol. Wirkung

Nicht-selektiver muskarinischer Acetylcholin-Rezeptoragonist, verwendet für ein experimentelles Epilepsiemodell.

Piktogramme

Flame over circleSkull and crossbones
GHS03,GHS06

Signalwort

Danger

Gefahreneinstufungen

Acute Tox. 2 Inhalation - Acute Tox. 4 Oral - Ox. Sol. 2

Lagerklassenschlüssel

5.1B - Oxidizing hazardous materials

WGK

WGK 3

Flammpunkt (°F)

Not applicable

Flammpunkt (°C)

Not applicable

Persönliche Schutzausrüstung

Eyeshields, Faceshields, Gloves, type P3 (EN 143) respirator cartridges

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Analysenzertifikate (COA)

Lot/Batch Number
SLCJ0525
SLCC1969
SLCC1429
SLCC1435
SLBX7300

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Olav B Smeland et al.
Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism, 33(7), 1090-1097 (2013-04-25)
Although certain metabolic characteristics such as interictal glucose hypometabolism are well established for temporal lobe epilepsy (TLE), its pathogenesis still remains unclear. Here, we performed a comprehensive study of brain metabolism in a mouse model of TLE, induced by pilocarpine-status
Rashmi M Risbud et al.
PloS one, 8(1), e53464-e53464 (2013-01-12)
MicroRNAs regulate protein synthesis by binding non-translated regions of mRNAs and suppressing translation and/or increasing mRNA degradation. MicroRNAs play an important role in the nervous system including controlling synaptic plasticity. Their expression is altered in disease states including stroke, head
Georgette L Suidan et al.
Arteriosclerosis, thrombosis, and vascular biology, 33(9), 2112-2120 (2013-07-05)
Aberrant blood-brain barrier (BBB) permeability is a hallmark pathology of many central nervous system diseases. von Willebrand factor (VWF) is stored in endothelial Weibel-Palade bodies from where it is released on activation into plasma and basement membrane. The role of
Linda Holtman et al.
Epilepsia, 54(4), 589-595 (2013-02-13)
Brain inflammation occurs during epileptogenesis and may contribute to the development and progression of temporal lobe epilepsy. Recently, several studies have indicated that seizures may also increase specific blood plasma cytokine levels in animal models as well as in human
Kathleen Heng et al.
Epilepsia, 54(9), 1535-1541 (2013-07-16)
The role of granule cell axon (mossy fiber) sprouting in temporal lobe epileptogenesis is unclear and controversial. Rapamycin suppresses mossy fiber sprouting, but its reported effects on seizure frequency are mixed. The present study used high-dose rapamycin to more completely
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