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I114

Supelco

p-Iodclonidin -hydrochlorid

analytical standard, for drug analysis

Synonym(e):

2-[(2,6-Dichlor-4-iodphenyl)-imino]-imidazolin -hydrochlorid

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About This Item

Empirische Formel (Hill-System):
C9H8Cl2IN3 · HCl
CAS-Nummer:
108294-53-7
Molekulargewicht:
392.45
MDL-Nummer:
MFCD00069292
UNSPSC-Code:
41116107
PubChem Substanz-ID:
329815344
NACRES:
NA.24

Qualität

analytical standard, for drug analysis

Qualitätsniveau

100

Form

solid

Methode(n)

HPLC: suitable
gas chromatography (GC): suitable

Farbe

white to off-white

Löslichkeit

H2O: soluble

Anwendung(en)

forensics and toxicology
pharmaceutical (small molecule)
veterinary

Format

neat

SMILES String

Cl[H].Clc1cc(I)cc(Cl)c1\N=C2/NCCN2

InChI

1S/C9H8Cl2IN3.ClH/c10-6-3-5(12)4-7(11)8(6)15-9-13-1-2-14-9;/h3-4H,1-2H2,(H2,13,14,15);1H

InChIKey

ULCGXOSKNHMYAX-UHFFFAOYSA-N

Angaben zum Gen

human ... ADRA2A(150) , ADRA2B(151) , ADRA2C(152)

Anwendung

Refer to the product′s Certificate of Analysis for more information on a suitable instrument technique. Contact Technical Service for further support.

Biochem./physiol. Wirkung

α2 adrenerger Rezeptor-Agonist mit hoher Affinität

Piktogramme

Exclamation mark
GHS07

Signalwort

Warning

Gefahreneinstufungen

Acute Tox. 4 Dermal - Acute Tox. 4 Inhalation - Acute Tox. 4 Oral

Lagerklassenschlüssel

11 - Combustible Solids

WGK

WGK 3

Flammpunkt (°F)

Not applicable

Flammpunkt (°C)

Not applicable

Persönliche Schutzausrüstung

dust mask type N95 (US), Eyeshields, Gloves

Hier finden Sie alle aktuellen Versionen:

Analysenzertifikate (COA)

Lot/Batch Number
118H4709

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H Zhu et al.
Life sciences, 61(19), 1973-1983 (1997-01-01)
One subtype of imidazoline receptors (IR1) is similar to alpha 2-adrenoceptors (alpha 2 AR) based on their high affinity for clonidine and related imidazoline compounds. On the other hand, IR1 possess low affinity for norepinephrine (NE) and other catecholamines. Imidazoline
N Benedetto et al.
Pathologie-biologie, 45(1), 9-18 (1997-01-01)
We investigated the effects of alpha-adrenergic on the capacity of Toxoplasma gondii to invade and proliferate in cultured human umbilical vein endothelial cells. Pretreatment of human umbilical vein endothelial cells (HUVEC) with alpha 2-adrenergic led to a high degree of
J E Piletz et al.
Journal of psychiatric research, 32(2), 55-64 (1998-08-07)
A comparison is presented between plasma catecholamine concentrations and platelet [125I]-p-iodoclonidine binding sites in 16 healthy women. Blood samples were obtained at six regularly spaced intervals over two consecutive menstrual cycles from healthy women with regular menstrual periods. Although no
M Van Dort et al.
Journal of medicinal chemistry, 30(7), 1241-1244 (1987-07-01)
The chemical synthesis of 2-[(2,6-dichloro-4-iodophenyl)imino]imidazolidine (PIC) and its radioiodinated analogue [125I]PIC is described. PIC was synthesized from 2,6-dichloroaniline in five synthetic steps. This agent displayed a high affinity for the alpha 2-adrenergic receptor (IC50 = 1.5 nM) in competitive binding
F M Heemskerk et al.
Journal of neurochemistry, 71(5), 2193-2202 (1998-11-03)
Nonadrenergic imidazoline-specific binding sites were characterized pharmacologically in crude cerebral membrane preparations, but little is known about their subcellular localization in neurons. As in the brainstem these sites are involved in cardiovascular regulation and peripherally imidazolines modulate neurotransmitter release, we
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