BP253

Miconazolnitrat

British Pharmacopoeia (BP) Reference Standard

• Synonym(e): (±)-Miconazol -nitrat (Salz), 1-(2,4-Dichlor-β-[(2,4-dichlorbenzyl)-oxy]-phenethyl)-imidazol
• Empirische Formel (Hill-System): C₁₈H₁₄Cl₄N₂O · HNO₃
• CAS-Nummer: 22832-87-7
• Molekulargewicht: 479.14
• EG-Nummer: 245-256-6
• MDL-Nummer: MFCD00058161
• UNSPSC-Code: 41116107
• NACRES: NA.24

Eigenschaften

• Qualität: pharmaceutical primary standard
• API-Familie: miconazole
• Form: solid
• Haltbarkeit: limited shelf life, expiry date on the label
• Hersteller/Markenname: BP
• Anwendung(en): pharmaceutical; pharmaceutical small molecule
• Format: neat
• Lagertemp.: 2-8°C
• SMILES String: ClC1=CC(Cl)=CC=C1C(OCC2=CC=C(Cl)C=C2Cl)CN3C=CN=C3.[O-][N+](O)=O
• InChI: 1S/C18H14Cl4N2O.HNO3/c19-13-2-1-12(16(21)7-13)10-25-18(9-24-6-5-23-11-24)15-4-3-14(20)8-17(15)22;2-1(3)4/h1-8,11,18H,9-10H2;(H,2,3,4)
• InChIKey: MCCACAIVAXEFAL-UHFFFAOYSA-N

Beschreibung

Allgemeine Beschreibung

This product is provided as delivered and specified by the issuing Pharmacopoeia. All information provided in support of this product, including SDS and any product information leaflets have been developed and issued under the Authority of the issuing Pharmacopoeia. For further information and support please go to the website of the issuing Pharmacopoeia.

Anwendung

Miconazole nitrate BP Reference standard, intended for use in laboratory tests only as specifically prescribed in the British Pharmacopoeia.

Also used in monographs such as:

Miconazole and Hydrocortisone Acetate Cream

Miconazole and Hydrocortisone Cream

Miconazole and Hydrocortisone Ointment

Miconazole Eye Drops

Miconazole Oromucosal Gel

Miconazole Cream

Biochem./physiol. Wirkung

Miconazol interagiert mit 14-α-Demethylase, einem Cytochrom-P-450-Enzym, das für die Ergosterin-Biosynthese notwendig ist. Die Hemmung von Ergosterol führt zu einer erhöhten zellulären Permeabilität, was zum Leckverlust zellulärer Inhalte führt. Miconazol kann auch endogene Atmung inhibieren, mit Phospholipiden der Zellmembran interagieren, die Transformation von Hefen zu Myzel Formen hemmen, die Purin-Aufnahme hemmen und in die Triglycerid und Phospholipidbiosynthese eingreifen.

Verpackung

Unit quantity: 100 mg. Subject to change. The product is delivered as supplied by the issuing Pharmacopoeia. For the current unit quantity please visit British Pharmacopoeia

Sonstige Hinweise

Sales restrictions may apply.

Sicherheitshinweise

• Piktogramme: GHS07
• Signalwort: Warning
• H-Sätze: H302,H317
• P-Sätze: P280 - P301 + P312 + P330
• Gefahreneinstufungen: Acute Tox. 4 Oral - Skin Sens. 1
• Lagerklassenschlüssel: 11 - Combustible Solids
• WGK: WGK 3
• Flammpunkt (°F): Not applicable
• Flammpunkt (°C): Not applicable