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Merck

B3022

Supelco

Beclomethasondipropionate

analytical standard, for drug analysis

Synonym(e):

9-Chlor-11β,17,21-trihydroxy-16β-methylpregna-1,4-dien-3,20-dion-17,21-dipropionat

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About This Item

Empirische Formel (Hill-System):
C28H37ClO7
CAS-Nummer:
Molekulargewicht:
521.04
EG-Nummer:
MDL-Nummer:
UNSPSC-Code:
41116107
PubChem Substanz-ID:
NACRES:
NA.24

Qualität

analytical standard, for drug analysis

Qualitätsniveau

Assay

≥99%

Methode(n)

HPLC: suitable
gas chromatography (GC): suitable

Anwendung(en)

forensics and toxicology
veterinary

Format

neat

Lagertemp.

2-8°C

SMILES String

CCC(=O)OCC(=O)[C@@]1(OC(=O)CC)[C@@H](C)C[C@H]2[C@@H]3CCC4=CC(=O)C=C[C@]4(C)[C@@]3(Cl)[C@@H](O)C[C@]12C

InChI

1S/C28H37ClO7/c1-6-23(33)35-15-22(32)28(36-24(34)7-2)16(3)12-20-19-9-8-17-13-18(30)10-11-25(17,4)27(19,29)21(31)14-26(20,28)5/h10-11,13,16,19-21,31H,6-9,12,14-15H2,1-5H3/t16-,19-,20-,21-,25-,26-,27-,28-/m0/s1

InChIKey

KUVIULQEHSCUHY-XYWKZLDCSA-N

Angaben zum Gen

human ... NR3C1(2908)

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Allgemeine Beschreibung

Beclomethasone dipropionate belongs to the chemical class of chlorinated glucocorticoid diesters, well known for its use in the treatment of asthma due to its anti-inflammatory properties.

Anwendung

Beclomethasone dipropionate analytical standard can be used as follows:
  • Development of a reversed-phase high-performance liquid chromatographic (RP-HPLC) method, combined with UV detection to determine beclomethasone dipropionate in nanocapsule suspensions
  • Simultaneous determination of beclomethasone dipropionate and ketoconazole in their bulk and combined cream formulations using UV-spectrophotometry and RP-HPLC based methods
  • Estimation of beclomethasone dipropionate and formoterol fumarate in their combined dosage forms by stability indicating RP-HPLC method coupled with UV detection
  • Combined analysis of beclomethasone dipropionate and formoterol fumarate dihydrate using two UV-spectrometric and one RP-HPLC based methods in bulk and their pharmaceutical dosage forms
  • Multi-residue analysis of 21 glucocorticoids in environmental samples by ultra-high performance liquid chromatography (UHPLC) and mass spectrometry (MS)

Sonstige Hinweise

Refer to the product′s Certificate of Analysis for more information on a suitable instrument technique. Contact Technical Service for further support.

Piktogramme

Health hazard

Signalwort

Warning

H-Sätze

Gefahreneinstufungen

Repr. 2 - STOT RE 2

Zielorgane

Adrenal gland,Immune system,Bone

Lagerklassenschlüssel

11 - Combustible Solids

WGK

WGK 3

Flammpunkt (°F)

Not applicable

Flammpunkt (°C)

Not applicable

Persönliche Schutzausrüstung

Eyeshields, Gloves, type P3 (EN 143) respirator cartridges


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Die Dokumentenbibliothek aufrufen

Quick Review of Pharmacology null
Kai-Michael Beeh et al.
The Journal of allergy and clinical immunology, 131(3), 866-874 (2013-02-07)
Allergen-specific TH2 responses contribute to the development of allergic asthma. Their increase may be due to a reduced early exposure to environmental pathogens, which induces a TH1 response, and thereby suppresses the allergic TH2 response. QbG10 (bacteriophage Qbeta-derived virus-like particle
William J Anderson et al.
Annals of allergy, asthma & immunology : official publication of the American College of Allergy, Asthma, & Immunology, 109(3), 185-189 (2012-08-28)
Whether small airways dysfunction persists in patients with asthma receiving standard community treatment is unknown. Impulse oscillometry (IOS) is a sensitive measure of small airways function. To assess the degree of small airways dysfunction in a cross-section of patients with
Linjie Zhang et al.
Respirology (Carlton, Vic.), 18(2), 272-277 (2012-10-09)
Recent studies have raised concerns about the link between use of inhaled corticosteroids (ICS) and risk of pneumonia in patients with chronic obstructive pulmonary disease. This cross-sectional study aimed to investigate the association between ICS and oropharyngeal colonization by Streptococcus
Eli O Meltzer et al.
Allergy and asthma proceedings, 33(3), 249-257 (2012-06-28)
Intranasal corticosteroids are recommended as first-line therapy for the treatment of the symptoms of persistent allergic rhinitis (AR). Since the phase-out of chlorofluorocarbon nasal aerosols, intranasal corticosteroids have been available only as aqueous nasal sprays. This study was designed to

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