65943

N-Methyl-bis-trifluoracetamid

for GC derivatization, LiChropur^™, ≥99.0% (GC)

• Synonym(e): MBTFA
• Lineare Formel: CF₃CON(CH₃)COCF₃
• CAS-Nummer: 685-27-8
• Molekulargewicht: 223.07
• Beilstein: 1878402
• EG-Nummer: 211-680-5
• MDL-Nummer: MFCD00000412
• UNSPSC-Code: 12000000
• PubChem Substanz-ID: 329760134
• NACRES: NA.22

Eigenschaften

• Qualität: for GC derivatization; LiChropur^™
• Qualitätsniveau: 100
• Assay: ≥99.0% (GC)
• Eignung der Reaktion: reagent type: derivatization reagent; reaction type: Acylations; reagent type: derivatization reagent; reaction type: Silylations
• Methode(n): gas chromatography (GC): suitable
• Brechungsindex: n20/D 1.346 (lit.); n20/D 1.346
• bp: 121-122 °C (lit.)
• Dichte: 1.547 g/mL at 25 °C
• SMILES String: CN(C(=O)C(F)(F)F)C(=O)C(F)(F)F
• InChI: 1S/C5H3F6NO2/c1-12(2(13)4(6,7)8)3(14)5(9,10)11/h1H3
• InChIKey: AWGBWLXGUPTXHF-UHFFFAOYSA-N

Beschreibung

Allgemeine Beschreibung

N-Methyl-bis(trifluoroacetamide) is a common reagent used in the alkylation process, which targets highly polar, multi-functional compounds such as carbohydrates and amino acids.

Anwendung

N-Methyl-bis(trifluoroacetamide) may be used as an on-column derivatization agent for the determination of amphetamine-type stimulants in biological samples, and ketamine, norketamine, dehydronorketamine in urine samples using gas chromatography coupled to mass spectrometry technique.
It is a derivatization agent in GC-MS technique used as an alternative to trifluoroacetyl anhydride (TFAA) for trifluoroacylating primary and secondary amines, and the hydroxyl group under mild non-acidic conditions.
Reagent for introducing trifluoroacetyl group. Suitable for the derivatization of alcohols, amines, amino acids, carbohydrates(mono-,di-,tri- and tetrasaccharides, carboxylic acids, hydroxyamines, 3-hydroxy-1-nitrosopyrrolidine, indolalkylamine, phenolalkylamines, pyridoxal (and other B₆ vitamers), and thiols.

Reagenz für das Einführen einer Trifluoracetyl-Gruppe

Sonstige Hinweise

Reagens für Trifluoracetylierungen unter milden Bedingungen

Reagent for trifluoroacetyl, N-trimethylsilyl-N-tifluoroacetyl and trimethylsilyl.

Rechtliche Hinweise

LiChropur is a trademark of Merck KGaA, Darmstadt, Germany

Sicherheitshinweise

• Piktogramme: GHS02,GHS05
• Signalwort: Danger
• H-Sätze: H226,H314
• P-Sätze: P210 - P233 - P240 - P280 - P303 + P361 + P353 - P305 + P351 + P338
• Gefahreneinstufungen: Flam. Liq. 3 - Skin Corr. 1B
• Lagerklassenschlüssel: 3 - Flammable liquids
• WGK: WGK 3
• Flammpunkt (°F): 113.0 °F - closed cup
• Flammpunkt (°C): 45 °C - closed cup
• Persönliche Schutzausrüstung: Faceshields, Gloves, Goggles, type ABEK (EN14387) respirator filter