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Merck

61739

Sigma-Aldrich

N-Lauroylsarcosin

purum p.a., ≥98.0% (GC)

Synonym(e):

N-Dodecanoyl-N-methylglycin, Sarkosyl L

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About This Item

Lineare Formel:
CH3(CH2)10CON(CH3)CH2COOH
CAS-Nummer:
Molekulargewicht:
271.40
Beilstein:
1792084
EG-Nummer:
MDL-Nummer:
UNSPSC-Code:
12352100
PubChem Substanz-ID:
NACRES:
NA.21

Beschreibung

anionic

Qualitätsniveau

Qualität

purum p.a.

Assay

≥98.0% (GC)

Mol-Gew.

271.40 g/mol

Methode(n)

protein quantification: suitable

Verunreinigungen

≤0.2% water

Glührückstand

≤0.1%

mp (Schmelzpunkt)

45-50 °C

Anionenspuren

chloride (Cl-): ≤50 mg/kg
sulfate (SO42-): ≤100 mg/kg

Kationenspuren

Ca: ≤20 mg/kg
Cd: ≤5 mg/kg
Co: ≤5 mg/kg
Cr: ≤5 mg/kg
Cu: ≤5 mg/kg
Fe: ≤10 mg/kg
K: ≤70 mg/kg
Mg: ≤5 mg/kg
Mn: ≤5 mg/kg
Na: ≤200 mg/kg
Ni: ≤5 mg/kg
Pb: ≤5 mg/kg
Zn: ≤20 mg/kg

SMILES String

CCCCCCCCCCCC(=O)N(C)CC(O)=O

InChI

1S/C15H29NO3/c1-3-4-5-6-7-8-9-10-11-12-14(17)16(2)13-15(18)19/h3-13H2,1-2H3,(H,18,19)

InChIKey

BACYUWVYYTXETD-UHFFFAOYSA-N

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Allgemeine Beschreibung

N-Lauroylsarcosine (N-Dodecanoyl-N-methylglycine, Sarkosyl L, LS) is an anionic surfactant. Its microbicidal action against herpes simplex type 2 (HSV-2) intravaginal infection in a murine model has been investigated.

Anwendung

N-Lauroylsarcosine may be used as a permeation enhancer in the transdermal drug delivery formulations since it increases the fluidity of stratum corneum lipid structure of the skin

Piktogramme

Skull and crossbonesCorrosion

Signalwort

Danger

Gefahreneinstufungen

Acute Tox. 2 Inhalation - Eye Dam. 1 - Skin Irrit. 2

Lagerklassenschlüssel

6.1A - Combustible acute toxic Cat. 1 and 2 / very toxic hazardous materials

WGK

WGK 1

Flammpunkt (°F)

Not applicable

Flammpunkt (°C)

Not applicable

Persönliche Schutzausrüstung

dust mask type N95 (US), Eyeshields, Gloves


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Yeu-Chun Kim et al.
International journal of pharmaceutics, 352(1-2), 129-138 (2007-12-15)
To develop formulations for transdermal drug delivery, this study tested the hypothesis that the anionic surfactant, N-lauroylsarcosine (NLS), and ethanol synergistically increase skin permeability by increasing the fluidity of stratum corneum lipid structure. Skin permeability experiments showed that transdermal delivery
Kunie Ando et al.
The American journal of pathology, 178(2), 803-816 (2011-02-02)
Many models of human tauopathies have been generated in mice by expression of a human mutant tau with maintained expression of mouse endogenous tau. Because murine tau might interfere with the toxic effects of human mutant tau, we generated a
Yoshiaki Furukawa et al.
The Journal of biological chemistry, 286(21), 18664-18672 (2011-04-02)
The transactivation response element (TAR) DNA-binding protein-43 (TDP-43) is a nuclear protein that normally regulates transcription and splicing. Abnormal accumulation of insoluble inclusions containing TDP-43 has been recently reported in the affected tissues of amyotrophic lateral sclerosis (ALS) patients. Here
S Roy et al.
Antimicrobial agents and chemotherapy, 45(6), 1671-1681 (2001-05-17)
The microbicidal efficacies of two anionic surfactants, sodium lauryl sulfate (SLS) and n-lauroylsarcosine (LS), were evaluated in cultured cells and in a murine model of herpes simplex type 2 (HSV-2) intravaginal infection. In vitro studies showed that SLS and LS
Jian Sun et al.
Nucleic acids research, 43(14), 6827-6846 (2015-07-04)
The transcription factor Pax6 is comprised of the paired domain (PD) and homeodomain (HD). In the developing forebrain, Pax6 is expressed in ventricular zone precursor cells and in specific subpopulations of neurons; absence of Pax6 results in disrupted cell proliferation

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